MGP Database

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MGP002457

Ontology/Pathway Information

Entrez Gene ID5627
Gene Nameprotein S (alpha)
Gene Symbol PROS1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0072562 IDA:UniProtKBCblood microparticle
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0005576 NAS:UniProtKBCextracellular region
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005796 TAS:ReactomeCGolgi lumen
GO:0000139 TAS:ReactomeCGolgi membrane
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0005509 IEA:InterProFcalcium ion binding
GO:0004866 TAS:ProtIncFendopeptidase inhibitor activity
GO:0007596 TAS:ReactomePblood coagulation
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0042730 IEA:UniProtKB-KWPfibrinolysis
GO:0045087 TAS:ReactomePinnate immune response
GO:0050900 TAS:ReactomePleukocyte migration
GO:0010951 TAS:GOCPnegative regulation of endopeptidase activity
GO:0017187 TAS:ReactomePpeptidyl-glutamic acid carboxylation
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0043687 TAS:ReactomePpost-translational protein modification
GO:0006508 TAS:ReactomePproteolysis
GO:0030449 TAS:ReactomePregulation of complement activation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_12051Cell surface interactions at the vascular wall
REACT_1439Common Pathway
REACT_6932Complement cascade
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_1069Gamma carboxylation, hypusine formation and arylsulfatase activation
REACT_1050Gamma-carboxylation of protein precursors
REACT_1132Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_17015Metabolism of proteins
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_22161Post-translational protein modification
REACT_118707Regulation of Complement cascade
REACT_733Removal of aminoterminal propeptides from gamma-carboxylated proteins
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_1906Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
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