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MGP002465

UniProt Annotations

Entry Information
Gene Nameproteinase 3
Protein EntryPRTN3_HUMAN
UniProt IDP24158
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityHydrolysis of proteins, including elastin, by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-. {ECO:0000269|PubMed:7897245}.
FunctionPolymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.
Sequence CautionSequence=AAA36342.1; Type=Frameshift; Positions=34, 39; Evidence={ECO:0000305}; Sequence=CAA39598.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the peptidase S1 family. Elastase subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
SimilarityContains 1 peptidase S1 domain. {ECO:0000255|PROSITE- ProRule:PRU00274}.
Web ResourceName=Wikipedia; Note=Proteinase 3 entry; URL="http://en.wikipedia.org/wiki/Proteinase_3";
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