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MGP002495

UniProt Annotations

Entry Information
Gene Nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 3
Protein EntryPSMD3_HUMAN
UniProt IDO43242
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43242-1; Sequence=Displayed; Name=2; IsoId=O43242-2; Sequence=VSP_056362, VSP_056363; Note=No experimental confirmation available.;
FunctionActs as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
SimilarityBelongs to the proteasome subunit S3 family. {ECO:0000305}.
SimilarityContains 1 PCI domain. {ECO:0000305}.
SubunitThe 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively.
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