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MGP002496

UniProt Annotations

Entry Information
Gene Nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Protein EntryPSMD4_HUMAN
UniProt IDP55036
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=Rpn10A; IsoId=P55036-1; Sequence=Displayed; Name=Rpn10E; IsoId=P55036-2; Sequence=VSP_005291, VSP_005292; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.;
DomainThe 2 UIM motifs are involved in the binding to a multi- ubiquitin chain in a cooperative way.
FunctionBinds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion.
InteractionSelf; NbExp=3; IntAct=EBI-359318, EBI-359318; Q16186:ADRM1; NbExp=2; IntAct=EBI-359318, EBI-954387; P48510:DSK2 (xeno); NbExp=2; IntAct=EBI-359318, EBI-6174; Q9SII8:DSK2B (xeno); NbExp=3; IntAct=EBI-359318, EBI-4433040; P24610:Pax3 (xeno); NbExp=3; IntAct=EBI-359318, EBI-1208116; Q13200:PSMD2; NbExp=3; IntAct=EBI-359318, EBI-357648; P54725:RAD23A; NbExp=3; IntAct=EBI-359318, EBI-746453; Q84L32:RAD23A (xeno); NbExp=3; IntAct=EBI-359318, EBI-6394924; P54727:RAD23B; NbExp=12; IntAct=EBI-359318, EBI-954531; Q62921:Rbck1 (xeno); NbExp=3; IntAct=EBI-359318, EBI-7266339; Q9P0W5:SCHIP1; NbExp=2; IntAct=EBI-359318, EBI-1397509; P0CG48:UBC; NbExp=8; IntAct=EBI-359318, EBI-3390054; Q9UMX0:UBQLN1; NbExp=6; IntAct=EBI-359318, EBI-741480; Q9UHD9:UBQLN2; NbExp=3; IntAct=EBI-359318, EBI-947187; Q9Y5K5:UCHL5; NbExp=5; IntAct=EBI-359318, EBI-1051183;
SimilarityBelongs to the proteasome subunit S5A family. {ECO:0000305}.
SimilarityContains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule:PRU00219}.
SimilarityContains 2 UIM (ubiquitin-interacting motif) domains. {ECO:0000255|PROSITE-ProRule:PRU00213}.
SubunitThe 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively. Directly interacts with NUB1. Interacts with SQSTM1. Interacts with UBQLN4. Interacts with UBE3A. {ECO:0000269|PubMed:11585840, ECO:0000269|PubMed:12970176, ECO:0000269|PubMed:14585839, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:22645313}.
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