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MGP002501

Record overview

MGPD IDMGP002501
Gene ID5716
SpeciesHomo sapiens (Human)
Gene Nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 10
Gene Symbol PSMD10
Synonymsp28; p28(GANK); dJ889N15.2;
Alternate names26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; ankyrin repeat protein; gankyrin; hepatocellular carcinoma-associated protein p28-II;
ChromosomeX
Map LocationXq22.3
SummaryThis gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]
OrthologsView orthologs and multiple alignments for PSMD10

Proteins

26S proteasome non-ATPase regulatory subunit 10 isoform 1
Refseq ID:NP_002805
Protein GI:4506217
UniProt ID:O75832
mRNA ID:NM_002814
Length:226
RefSeq Status:
MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN
AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYI
ENKEEKTPLQVAKGGLGLILKRMVEG
 
26S proteasome non-ATPase regulatory subunit 10 isoform 2
Refseq ID:NP_736606
Protein GI:28605137
UniProt ID:O75832
mRNA ID:NM_170750
Length:151
RefSeq Status:
MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN
AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKDT
 
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