MGP Database

MGP002510

Ontology/Pathway Information

Entrez Gene ID	5727
Gene Name	patched 1
Gene Symbol	PTCH1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0044295	IEA:Ensembl	C	axonal growth cone
GO:0005901	IDA:BHF-UCL	C	caveola
GO:0044294	IEA:Ensembl	C	dendritic growth cone
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0043231	IDA:BHF-UCL	C	intracellular membrane-bounded organelle
GO:0030496	IEA:Ensembl	C	midbody
GO:0048471	IDA:BHF-UCL	C	perinuclear region of cytoplasm
GO:0005886	IDA:BHF-UCL	C	plasma membrane
GO:0014069	IEA:Ensembl	C	postsynaptic density
GO:0072372	IEA:Ensembl	C	primary cilium
GO:0015485	IDA:BHF-UCL	F	cholesterol binding
GO:0030332	IPI:BHF-UCL	F	cyclin binding
GO:0097108	IPI:BHF-UCL	F	hedgehog family protein binding
GO:0008158	IEA:InterPro	F	hedgehog receptor activity
GO:0008201	IEA:Ensembl	F	heparin binding
GO:0005119	IPI:BHF-UCL	F	smoothened binding
GO:0007420	ISS:BHF-UCL	P	brain development
GO:0001658	IEA:Ensembl	P	branching involved in ureteric bud morphogenesis
GO:0061005	IEA:Ensembl	P	cell differentiation involved in kidney development
GO:0072203	IEA:Ensembl	P	cell proliferation involved in metanephros development
GO:0071397	IMP:BHF-UCL	P	cellular response to cholesterol
GO:0009953	ISS:UniProtKB	P	dorsal/ventral pattern formation
GO:0030326	ISS:UniProtKB	P	embryonic limb morphogenesis
GO:0048568	IEA:Ensembl	P	embryonic organ development
GO:0008544	IEA:Ensembl	P	epidermis development
GO:0042593	IEA:Ensembl	P	glucose homeostasis
GO:0003007	IEA:Ensembl	P	heart morphogenesis
GO:0035137	IEA:Ensembl	P	hindlimb morphogenesis
GO:0001701	IEA:Ensembl	P	in utero embryonic development
GO:0043616	IEA:Ensembl	P	keratinocyte proliferation
GO:0035108	IMP:BHF-UCL	P	limb morphogenesis
GO:0060603	IEA:Ensembl	P	mammary gland duct morphogenesis
GO:0060644	IEA:Ensembl	P	mammary gland epithelial cell differentiation
GO:0051782	IEA:Ensembl	P	negative regulation of cell division
GO:0050680	IEA:Ensembl	P	negative regulation of epithelial cell proliferation
GO:0040015	ISS:UniProtKB	P	negative regulation of multicellular organism growth
GO:0045668	IMP:BHF-UCL	P	negative regulation of osteoblast differentiation
GO:0043433	IMP:BHF-UCL	P	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045879	ISS:BHF-UCL	P	negative regulation of smoothened signaling pathway
GO:0000122	IMP:BHF-UCL	P	negative regulation of transcription from RNA polymerase II promoter
GO:0021997	ISS:BHF-UCL	P	neural plate axis specification
GO:0001843	IEA:Ensembl	P	neural tube closure
GO:0021532	IMP:BHF-UCL	P	neural tube patterning
GO:0009887	ISS:UniProtKB	P	organ morphogenesis
GO:0060037	IMP:BHF-UCL	P	pharyngeal system development
GO:0010875	IDA:BHF-UCL	P	positive regulation of cholesterol efflux
GO:0016485	ISS:UniProtKB	P	protein processing
GO:0072661	IDA:BHF-UCL	P	protein targeting to plasma membrane
GO:0007346	IEA:Ensembl	P	regulation of mitotic cell cycle
GO:0032880	IEA:Ensembl	P	regulation of protein localization
GO:0008589	ISS:UniProtKB	P	regulation of smoothened signaling pathway
GO:0072001	IEP:UniProtKB	P	renal system development
GO:0010157	IEA:Ensembl	P	response to chlorate
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0009612	IEA:Ensembl	P	response to mechanical stimulus
GO:0032526	IEA:Ensembl	P	response to retinoic acid
GO:0007224	IEP:UniProtKB	P	smoothened signaling pathway
GO:0060831	IEA:Ensembl	P	smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061053	IMP:BHF-UCL	P	somite development
GO:0021522	IEA:Ensembl	P	spinal cord motor neuron differentiation

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_18372	Class B/2 (Secretin family receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_21340	GPCR ligand binding
REACT_268323	Hedgehog 'off' state
REACT_268718	Hedgehog 'on' state
REACT_268573	Ligand-receptor interactions
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_14797	Signaling by GPCR
REACT_264508	Signaling by Hedgehog
REACT_111102	Signal Transduction