MGP Database

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MGP002511

Ontology/Pathway Information

Entrez Gene ID5728
Gene Namephosphatase and tensin homolog
Gene Symbol PTEN
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0042995 IDA:UniProtKBCcell projection
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0009898 IDA:UniProtKBCcytoplasmic side of plasma membrane
GO:0005829 TAS:ReactomeCcytosol
GO:0043197 IEA:EnsemblCdendritic spine
GO:0005576 IEA:UniProtKB-SubCellCextracellular region
GO:0005739 IEA:EnsemblCmitochondrion
GO:0035749 ISS:BHF-UCLCmyelin sheath adaxonal region
GO:0043005 ISS:BHF-UCLCneuron projection
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:BHF-UCLCnucleus
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0016605 IEA:UniProtKB-SubCellCPML body
GO:0045211 IEA:EnsemblCpostsynaptic membrane
GO:0043220 ISS:BHF-UCLCSchmidt-Lanterman incisure
GO:0010997 IPI:BHF-UCLFanaphase-promoting complex binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0051717 IDA:UniProtKBFinositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0008289 IEA:UniProtKB-KWFlipid binding
GO:0000287 IEA:InterProFmagnesium ion binding
GO:0030165 IPI:UniProtKBFPDZ domain binding
GO:0016314 IDA:UniProtKBFphosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800 IDA:UniProtKBFphosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004438 IDA:UniProtKBFphosphatidylinositol-3-phosphatase activity
GO:0004721 IDA:BHF-UCLFphosphoprotein phosphatase activity
GO:0004722 IDA:UniProtKBFprotein serine/threonine phosphatase activity
GO:0004725 IDA:UniProtKBFprotein tyrosine phosphatase activity
GO:0008138 IEA:InterProFprotein tyrosine/serine/threonine phosphatase activity
GO:0007092 IDA:BHF-UCLPactivation of mitotic anaphase-promoting complex activity
GO:0007568 IEA:EnsemblPaging
GO:0001525 IEA:EnsemblPangiogenesis
GO:0006915 ISS:UniProtKBPapoptotic process
GO:0048854 ISS:BHF-UCLPbrain morphogenesis
GO:0060070 IDA:BHF-UCLPcanonical Wnt signaling pathway
GO:0048738 IEA:EnsemblPcardiac muscle tissue development
GO:0016477 ISS:UniProtKBPcell migration
GO:0008283 TAS:UniProtKBPcell proliferation
GO:0007417 ISS:UniProtKBPcentral nervous system development
GO:0032286 ISS:BHF-UCLPcentral nervous system myelin maintenance
GO:0021955 ISS:BHF-UCLPcentral nervous system neuron axonogenesis
GO:0060997 ISS:BHF-UCLPdendritic spine morphogenesis
GO:0021542 ISS:BHF-UCLPdentate gyrus development
GO:0043542 IEA:EnsemblPendothelial cell migration
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0048853 ISS:BHF-UCLPforebrain morphogenesis
GO:0007507 ISS:UniProtKBPheart development
GO:0045087 TAS:ReactomePinnate immune response
GO:0046855 IDA:UniProtKBPinositol phosphate dephosphorylation
GO:0043647 TAS:ReactomePinositol phosphate metabolic process
GO:0007611 ISS:BHF-UCLPlearning or memory
GO:0045475 ISS:BHF-UCLPlocomotor rhythm
GO:0007626 ISS:BHF-UCLPlocomotory behavior
GO:0060292 IEA:EnsemblPlong term synaptic depression
GO:0060291 IEA:EnsemblPlong-term synaptic potentiation
GO:0060179 IEA:EnsemblPmale mating behavior
GO:0042711 IEA:EnsemblPmaternal behavior
GO:0007613 IEA:EnsemblPmemory
GO:0033555 ISS:BHF-UCLPmulticellular organismal response to stress
GO:0043066 IEA:EnsemblPnegative regulation of apoptotic process
GO:0050771 ISS:BHF-UCLPnegative regulation of axonogenesis
GO:0090344 IEA:EnsemblPnegative regulation of cell aging
GO:0030336 IMP:UniProtKBPnegative regulation of cell migration
GO:0008285 IMP:UniProtKBPnegative regulation of cell proliferation
GO:0045792 ISS:BHF-UCLPnegative regulation of cell size
GO:0031658 IDA:BHF-UCLPnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0061002 ISS:BHF-UCLPnegative regulation of dendritic spine morphogenesis
GO:0050680 IEA:EnsemblPnegative regulation of epithelial cell proliferation
GO:0090394 ISS:BHF-UCLPnegative regulation of excitatory postsynaptic membrane potential
GO:0051895 IMP:UniProtKBPnegative regulation of focal adhesion assembly
GO:2000134 IDA:BHF-UCLPnegative regulation of G1/S transition of mitotic cell cycle
GO:0031642 IEA:EnsemblPnegative regulation of myelination
GO:0046621 ISS:BHF-UCLPnegative regulation of organ growth
GO:0050765 IEA:EnsemblPnegative regulation of phagocytosis
GO:0014067 TAS:BHF-UCLPnegative regulation of phosphatidylinositol 3-kinase signaling
GO:0051898 IMP:UniProtKBPnegative regulation of protein kinase B signaling
GO:0001933 IDA:BHF-UCLPnegative regulation of protein phosphorylation
GO:0090071 IEA:EnsemblPnegative regulation of ribosome biogenesis
GO:2000808 ISS:BHF-UCLPnegative regulation of synaptic vesicle clustering
GO:0007270 ISS:BHF-UCLPneuron-neuron synaptic transmission
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0035335 IDA:GOCPpeptidyl-tyrosine dephosphorylation
GO:0006661 TAS:ReactomePphosphatidylinositol biosynthetic process
GO:0046856 IDA:UniProtKBPphosphatidylinositol dephosphorylation
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0006644 TAS:ReactomePphospholipid metabolic process
GO:0048008 IEA:EnsemblPplatelet-derived growth factor receptor signaling pathway
GO:2001235 IEA:EnsemblPpositive regulation of apoptotic signaling pathway
GO:0008284 ISS:BHF-UCLPpositive regulation of cell proliferation
GO:2000463 ISS:BHF-UCLPpositive regulation of excitatory postsynaptic membrane potential
GO:2000060 IDA:BHF-UCLPpositive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051091 IMP:BHF-UCLPpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0097107 ISS:BHF-UCLPpostsynaptic density assembly
GO:0060134 ISS:BHF-UCLPprepulse inhibition
GO:0097105 ISS:BHF-UCLPpresynaptic membrane assembly
GO:0060736 IEA:EnsemblPprostate gland growth
GO:0006470 IDA:UniProtKBPprotein dephosphorylation
GO:0043491 ISS:UniProtKBPprotein kinase B signaling
GO:0050821 IDA:BHF-UCLPprotein stabilization
GO:0002902 IEA:EnsemblPregulation of B cell apoptotic process
GO:0032535 ISS:BHF-UCLPregulation of cellular component size
GO:0000079 TAS:UniProtKBPregulation of cyclin-dependent protein serine/threonine kinase activity
GO:0033032 IEA:EnsemblPregulation of myeloid cell apoptotic process
GO:0010975 ISS:UniProtKBPregulation of neuron projection development
GO:0031647 IMP:UniProtKBPregulation of protein stability
GO:0046685 IEA:EnsemblPresponse to arsenic-containing substance
GO:0033198 IEA:EnsemblPresponse to ATP
GO:0042493 IEA:EnsemblPresponse to drug
GO:0032355 IEA:EnsemblPresponse to estradiol
GO:0045471 IEA:EnsemblPresponse to ethanol
GO:0009749 IEA:EnsemblPresponse to glucose
GO:0007584 IEA:EnsemblPresponse to nutrient
GO:0010043 IEA:EnsemblPresponse to zinc ion
GO:0060024 ISS:BHF-UCLPrhythmic synaptic transmission
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0035176 ISS:BHF-UCLPsocial behavior
GO:0007416 ISS:BHF-UCLPsynapse assembly
GO:0060074 ISS:BHF-UCLPsynapse maturation
GO:0050852 TAS:ReactomePT cell receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12555Downstream TCR signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_150154Inositol phosphate metabolism
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_12447Negative regulation of the PI3K/AKT network
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_120870Phospholipid metabolism
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_121175PI Metabolism
REACT_75829PIP3 activates AKT signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_150312Synthesis of IP3 and IP4 in the cytosol
REACT_121025Synthesis of PIPs at the plasma membrane
REACT_12526TCR signaling
SMP Pathway Links
SMP IDDescription
SMP00582Joubert syndrome
SMP00463Phosphatidylinositol Phosphate Metabolism
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