MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002513

Record overview

MGPD IDMGP002513
Gene ID5730
SpeciesHomo sapiens (Human)
Gene Nameprostaglandin D2 synthase 21kDa (brain)
Gene Symbol PTGDS
SynonymsPDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS;
Alternate namesprostaglandin-H2 D-isomerase; PGD2 synthase; beta-trace protein; cerebrin-28; glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin D synthase; lipocalin-type prostaglandin-D synthase; prostaglandin D synthase; prostaglandin-D2 synthase;
Chromosome9
Map Location9q34.2-q34.3
EC Number5.3.99.2
SummaryThe protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PTGDS

Proteins

prostaglandin-H2 D-isomerase precursor
Refseq ID:NP_000945
Protein GI:32171249
UniProt ID:P41222
mRNA ID:NM_000954
Length:190
RefSeq Status:
MATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAG
SLGSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFLPQTDKCMTEQ
 
sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2349
peptide sequence: 
MATHHTLWMGLALLGVLGDLQA
 
  logo