MGP Database

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MGP002523

Ontology/Pathway Information

Entrez Gene ID5743
Gene Nameprostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Gene Symbol PTGS2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005901 IEA:EnsemblCcaveola
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0043005 IDA:MGICneuron projection
GO:0005634 ISS:UniProtKBCnucleus
GO:0043234 IEA:EnsemblCprotein complex
GO:0050473 TAS:ReactomeFarachidonate 15-lipoxygenase activity
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0020037 ISS:UniProtKBFheme binding
GO:0008289 IEA:EnsemblFlipid binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004601 NAS:UniProtKBFperoxidase activity
GO:0004666 IDA:UniProtKBFprostaglandin-endoperoxide synthase activity
GO:0001525 IEA:EnsemblPangiogenesis
GO:0019369 TAS:ReactomeParachidonic acid metabolic process
GO:0030282 IEA:EnsemblPbone mineralization
GO:0050873 IEA:EnsemblPbrown fat cell differentiation
GO:0006928 TAS:ProtIncPcellular component movement
GO:0071318 IEA:EnsemblPcellular response to ATP
GO:0071456 IEP:UniProtKBPcellular response to hypoxia
GO:0071260 IEA:EnsemblPcellular response to mechanical stimulus
GO:0034644 IEA:EnsemblPcellular response to UV
GO:0019371 IDA:BHF-UCLPcyclooxygenase pathway
GO:0046697 IEA:EnsemblPdecidualization
GO:0007566 IEA:EnsemblPembryo implantation
GO:0042633 IEA:EnsemblPhair cycle
GO:0006954 IEA:EnsemblPinflammatory response
GO:0007612 IEA:EnsemblPlearning
GO:0019372 TAS:ReactomePlipoxygenase pathway
GO:0035633 IEA:EnsemblPmaintenance of blood-brain barrier
GO:0007613 IEA:EnsemblPmemory
GO:0051926 IEA:EnsemblPnegative regulation of calcium ion transport
GO:0045786 IEA:EnsemblPnegative regulation of cell cycle
GO:0008285 IEA:EnsemblPnegative regulation of cell proliferation
GO:0045986 IEA:EnsemblPnegative regulation of smooth muscle contraction
GO:0032227 IEA:EnsemblPnegative regulation of synaptic transmission, dopaminergic
GO:0030728 IEA:EnsemblPovulation
GO:0043065 IEA:EnsemblPpositive regulation of apoptotic process
GO:0090336 ISS:BHF-UCLPpositive regulation of brown fat cell differentiation
GO:0090050 ISS:BHF-UCLPpositive regulation of cell migration involved in sprouting angiogenesis
GO:0031622 ISS:BHF-UCLPpositive regulation of fever generation
GO:0090271 ISS:BHF-UCLPpositive regulation of fibroblast growth factor production
GO:0042346 IEA:EnsemblPpositive regulation of NF-kappaB import into nucleus
GO:0045429 ISS:BHF-UCLPpositive regulation of nitric oxide biosynthetic process
GO:0090362 ISS:BHF-UCLPpositive regulation of platelet-derived growth factor production
GO:0031394 NAS:BHF-UCLPpositive regulation of prostaglandin biosynthetic process
GO:0048661 IEA:EnsemblPpositive regulation of smooth muscle cell proliferation
GO:0045987 IEA:EnsemblPpositive regulation of smooth muscle contraction
GO:0031915 IEA:EnsemblPpositive regulation of synaptic plasticity
GO:0051968 IEA:EnsemblPpositive regulation of synaptic transmission, glutamatergic
GO:0071636 ISS:BHF-UCLPpositive regulation of transforming growth factor beta production
GO:0045907 IEA:EnsemblPpositive regulation of vasoconstriction
GO:0010575 ISS:BHF-UCLPpositive regulation vascular endothelial growth factor production
GO:0001516 ISS:UniProtKBPprostaglandin biosynthetic process
GO:0006693 TAS:ProtIncPprostaglandin metabolic process
GO:0008217 ISS:UniProtKBPregulation of blood pressure
GO:0050727 NAS:UniProtKBPregulation of inflammatory response
GO:0042493 IEA:EnsemblPresponse to drug
GO:0032355 IEA:EnsemblPresponse to estradiol
GO:0070542 IEA:EnsemblPresponse to fatty acid
GO:0009750 IEA:EnsemblPresponse to fructose
GO:0051384 IEA:EnsemblPresponse to glucocorticoid
GO:0032496 IEA:EnsemblPresponse to lipopolysaccharide
GO:0010226 IEA:EnsemblPresponse to lithium ion
GO:0010042 IEA:EnsemblPresponse to manganese ion
GO:0006979 IEA:InterProPresponse to oxidative stress
GO:0034612 IEA:EnsemblPresponse to tumor necrosis factor
GO:0033280 IEA:EnsemblPresponse to vitamin D
GO:0019233 IEA:EnsemblPsensory perception of pain
GO:0044281 TAS:ReactomePsmall molecule metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147851Arachidonic acid metabolism
REACT_169280Defective AMN causes hereditary megaloblastic anemia 1
REACT_169403Defective BTD causes biotidinase deficiency
REACT_169178Defective CD320 causes methylmalonic aciduria
REACT_169132Defective CUBN causes hereditary megaloblastic anemia 1
REACT_169415Defective GIF causes intrinsic factor deficiency
REACT_169312Defective HLCS causes multiple carboxylase deficiency
REACT_169363Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
REACT_169316Defective MMAA causes methylmalonic aciduria type cblA
REACT_169318Defective MMAB causes methylmalonic aciduria type cblB
REACT_169169Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
REACT_169256Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
REACT_169149Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
REACT_169439Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
REACT_169313Defective MUT causes methylmalonic aciduria mut type
REACT_169120Defective TCN2 causes hereditary megaloblastic anemia
REACT_169238Defects in biotin (Btn) metabolism
REACT_169429Defects in cobalamin (B12) metabolism
REACT_169385Defects in vitamin and cofactor metabolism
REACT_116125Disease
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_11193Metabolism of vitamins and cofactors
REACT_11238Metabolism of water-soluble vitamins and cofactors
REACT_11213Nicotinamide salvaging
REACT_11088Nicotinate metabolism
REACT_150422Synthesis of 15-eicosatetraenoic acid derivatives
REACT_150149Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
SMP Pathway Links
SMP IDDescription
SMP00710Acetaminophen Action Pathway
SMP00083Acetylsalicylic Acid Action Pathway
SMP00692Antipyrine Action Pathway
SMP00693Antrafenine Action Pathway
SMP00075Arachidonic Acid Metabolism
SMP00102Bromfenac Action Pathway
SMP00694Carprofen Action Pathway
SMP00096Celecoxib Action Pathway
SMP00644Celecoxib Metabolism Pathway
SMP00093Diclofenac Action Pathway
SMP00289Diflunisal Action Pathway
SMP00084Etodolac Action Pathway
SMP00442Etoposide Action Pathway
SMP00601Etoposide Metabolism Pathway
SMP00695Etoricoxib Action Pathway
SMP00696Fenoprofen Action Pathway
SMP00697Flurbiprofen Action Pathway
SMP00086Ibuprofen Action Pathway
SMP00590Ibuprofen Metabolism Pathway
SMP00104Indomethacin Action Pathway
SMP00085Ketoprofen Action Pathway
SMP00098Ketorolac Action Pathway
SMP00353Leukotriene C4 Synthesis Deficiency
SMP00700Lornoxicam Action Pathway
SMP00699Lumiracoxib Action Pathway
SMP00698Magnesium salicylate Action Pathway
SMP00109Mefenamic Acid Action Pathway
SMP00106Meloxicam Action Pathway
SMP00114Nabumetone Action Pathway
SMP00120Naproxen Action Pathway
SMP00702Nepafenac Action Pathway
SMP00113Oxaprozin Action Pathway
SMP00701Phenylbutazone Action Pathway
SMP00077Piroxicam Action Pathway
SMP00087Rofecoxib Action Pathway
SMP00708Salicylate-sodium Action Pathway
SMP00709Salicylic Acid Action Pathway
SMP00707Salsalate Action Pathway
SMP00094Sulindac Action Pathway
SMP00101Suprofen Action Pathway
SMP00706Tenoxicam Action Pathway
SMP00705Tiaprofenic Acid Action Pathway
SMP00704Tolmetin Action Pathway
SMP00703Trisalicylate-choline Action Pathway
SMP00116Valdecoxib Action Pathway
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