MGP Database

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MGP002534

Ontology/Pathway Information

Entrez Gene ID5805
Gene Name6-pyruvoyltetrahydropterin synthase
Gene Symbol PTS
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:LIFEdbCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005739 IDA:LIFEdbCmitochondrion
GO:0003874 TAS:ReactomeF6-pyruvoyltetrahydropterin synthase activity
GO:0042802 IPI:IntActFidentical protein binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0006520 TAS:ProtIncPcellular amino acid metabolic process
GO:0007417 TAS:ProtIncPcentral nervous system development
GO:0046209 TAS:ReactomePnitric oxide metabolic process
GO:0050999 TAS:ReactomePregulation of nitric-oxide synthase activity
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006729 TAS:ProtIncPtetrahydrobiopterin biosynthetic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_12389eNOS activation and regulation
REACT_111217Metabolism
REACT_12508Metabolism of nitric oxide
REACT_111176Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
SMP Pathway Links
SMP IDDescription
SMP00486Dopa-responsive dystonia
SMP00487Hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency
SMP00488Hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase deficiency (ptps)
SMP00489Hyperphenylalaninemia due to dhpr-deficiency
SMP00005Pterine Biosynthesis
SMP00490Segawa syndrome
SMP00491Sepiapterin reductase deficiency
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