MGP Database

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MGP002559

Ontology/Pathway Information

Entrez Gene ID5879
Gene Nameras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Gene Symbol RAC1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0036464 IDA:ParkinsonsUK-UCLCcytoplasmic ribonucleoprotein granule
GO:0005829 ISS:UniProtKBCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0019897 IEA:EnsemblCextrinsic component of plasma membrane
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0000139 IEA:EnsemblCGolgi membrane
GO:0030027 IDA:UniProtKBClamellipodium
GO:0042470 IEA:UniProtKB-SubCellCmelanosome
GO:0016020 ISS:UniProtKBCmembrane
GO:0001891 IEA:EnsemblCphagocytic cup
GO:0005886 TAS:ReactomeCplasma membrane
GO:0032587 IEA:EnsemblCruffle membrane
GO:0005802 IDA:FlyBaseCtrans-Golgi network
GO:0019899 IPI:BHF-UCLFenzyme binding
GO:0003924 TAS:UniProtKBFGTPase activity
GO:0005525 IDA:UniProtKBFGTP binding
GO:0051022 ISS:UniProtKBFRho GDP-dissociation inhibitor binding
GO:0031996 IPI:UniProtKBFthioesterase binding
GO:0030036 IGI:MGIPactin cytoskeleton organization
GO:0030041 TAS:UniProtKBPactin filament polymerization
GO:0048532 IEA:EnsemblPanatomical structure arrangement
GO:0009653 TAS:ProtIncPanatomical structure morphogenesis
GO:0097190 TAS:ReactomePapoptotic signaling pathway
GO:0002093 IEA:EnsemblPauditory receptor cell morphogenesis
GO:0007411 TAS:ReactomePaxon guidance
GO:0007596 TAS:ReactomePblood coagulation
GO:0045453 IEA:EnsemblPbone resorption
GO:0007155 TAS:ProtIncPcell adhesion
GO:0045216 IEA:EnsemblPcell-cell junction organization
GO:0007160 NAS:BHF-UCLPcell-matrix adhesion
GO:0048870 IDA:UniProtKBPcell motility
GO:0008283 IEA:EnsemblPcell proliferation
GO:0006928 TAS:ProtIncPcellular component movement
GO:0021799 IEA:EnsemblPcerebral cortex radially oriented cell migration
GO:0090103 IEA:EnsemblPcochlea morphogenesis
GO:0048813 IEA:EnsemblPdendrite morphogenesis
GO:0071542 IEA:EnsemblPdopaminergic neuron differentiation
GO:0021831 IEA:EnsemblPembryonic olfactory bulb interneuron precursor migration
GO:0043652 IEA:EnsemblPengulfment of apoptotic cell
GO:0003382 IEA:EnsemblPepithelial cell morphogenesis
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0007186 IEA:EnsemblPG-protein coupled receptor signaling pathway
GO:0006184 TAS:GOCPGTP catabolic process
GO:0006972 IEA:EnsemblPhyperosmotic response
GO:0006954 TAS:ProtIncPinflammatory response
GO:0045087 TAS:ReactomePinnate immune response
GO:0035556 TAS:ProtIncPintracellular signal transduction
GO:0030032 IMP:UniProtKBPlamellipodium assembly
GO:0051668 IMP:BHF-UCLPlocalization within membrane
GO:0002551 IEA:EnsemblPmast cell chemotaxis
GO:0032707 IDA:BHF-UCLPnegative regulation of interleukin-23 production
GO:0048261 TAS:UniProtKBPnegative regulation of receptor-mediated endocytosis
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0030168 TAS:ReactomePplatelet activation
GO:0030838 IEA:EnsemblPpositive regulation of actin filament polymerization
GO:0043065 TAS:ReactomePpositive regulation of apoptotic process
GO:0010811 IGI:UniProtKBPpositive regulation of cell-substrate adhesion
GO:0045740 IEA:EnsemblPpositive regulation of DNA replication
GO:0051894 IDA:UniProtKBPpositive regulation of focal adhesion assembly
GO:0010592 IMP:UniProtKBPpositive regulation of lamellipodium assembly
GO:0090023 IMP:UniProtKBPpositive regulation of neutrophil chemotaxis
GO:0043552 IEA:EnsemblPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0001934 IMP:UniProtKBPpositive regulation of protein phosphorylation
GO:0035025 TAS:UniProtKBPpositive regulation of Rho protein signal transduction
GO:0051496 IDA:UniProtKBPpositive regulation of stress fiber assembly
GO:1900026 IDA:UniProtKBPpositive regulation of substrate adhesion-dependent cell spreading
GO:0072659 IEA:EnsemblPprotein localization to plasma membrane
GO:0030334 IMP:UniProtKBPregulation of cell migration
GO:0050690 TAS:ReactomePregulation of defense response to virus by virus
GO:0010310 TAS:BHF-UCLPregulation of hydrogen peroxide metabolic process
GO:0060263 IDA:BHF-UCLPregulation of respiratory burst
GO:0009611 TAS:ProtIncPresponse to wounding
GO:0097178 IEA:EnsemblPruffle assembly
GO:0031529 TAS:UniProtKBPruffle organization
GO:0071526 ISS:UniProtKBPsemaphorin-plexin signaling pathway
GO:0007264 IEA:EnsemblPsmall GTPase mediated signal transduction
GO:0034446 IMP:UniProtKBPsubstrate adhesion-dependent cell spreading
GO:0031295 TAS:ReactomePT cell costimulation
GO:0016032 TAS:ReactomePviral process
GO:0060071 IEA:EnsemblPWnt signaling pathway, planar cell polarity pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_19226Activation of Rac
REACT_75774Adaptive Immune System
REACT_18266Axon guidance
REACT_264224beta-catenin independent WNT signaling
REACT_19183CD28 co-stimulation
REACT_19238CD28 dependent Vav1 pathway
REACT_111155Cell-Cell communication
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_19344Costimulation by the CD28 family
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_22351DCC mediated attractive signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_25299DSCAM interactions
REACT_263952EPHB-mediated forward signaling
REACT_264198EPH-ephrin mediated repulsion of cells
REACT_264068EPH-Ephrin signaling
REACT_264047Ephrin signaling
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_18407G alpha (12/13) signalling events
REACT_19184GPCR downstream signaling
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_6185HIV Infection
REACT_6288Host Interactions of HIV factors
REACT_6900Immune System
REACT_19342Inactivation of Cdc42 and Rac
REACT_6802Innate Immune System
REACT_22205L1CAM interactions
REACT_11123Membrane Trafficking
REACT_11068Nef and signal transduction
REACT_22237Netrin-1 signaling
REACT_13638NRAGE signals death through JNK
REACT_13776p75 NTR receptor-mediated signalling
REACT_264199PCP/CE pathway
REACT_798Platelet activation, signaling and aggregation
REACT_160086Regulation of actin dynamics for phagocytic cup formation
REACT_19236Sema3A PAK dependent Axon repulsion
REACT_19279SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
REACT_19277Sema4D induced cell migration and growth-cone collapse
REACT_19259Sema4D in semaphorin signaling
REACT_19266Sema4D mediated inhibition of cell attachment and migration
REACT_19271Semaphorin interactions
REACT_14797Signaling by GPCR
REACT_19351Signaling by Robo receptor
REACT_111040Signaling by SCF-KIT
REACT_12529Signaling by VEGF
REACT_11045Signaling by Wnt
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_22272Signal transduction by L1
REACT_6835The role of Nef in HIV-1 replication and disease pathogenesis
REACT_147867Translocation of GLUT4 to the plasma membrane
REACT_264464VEGFA-VEGFR2 Pathway
REACT_263991VEGFR2 mediated vascular permeability
SMP Pathway Links
SMP IDDescription
SMP00427Azathioprine Action Pathway
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
SMP00428Mercaptopurine Action Pathway
SMP00609Mercaptopurine Metabolism Pathway
SMP00430Thioguanine Action Pathway
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