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MGP002565

UniProt Annotations

Entry Information
Gene NameRAD23 homolog A (S. cerevisiae)
Protein EntryRD23A_HUMAN
UniProt IDP54725
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P54725-1; Sequence=Displayed; Name=2; IsoId=P54725-2; Sequence=VSP_047565; Note=No experimental confirmation available.; Name=3; IsoId=P54725-3; Sequence=VSP_054694; Note=No experimental confirmation available.;
DomainThe ubiquitin-like domain mediates interaction with ATXN3.
DomainThe ubiquitin-like (UBL) and the UBA (ubiquitin- associated) domains interact intramolecularly in a highly dynamic manner, as each UBA domain competes for an overlapping UBL domain surface. Binding of ubiquitin or proteasome subunit PSMD4 disrupt the UBL-UBA domain interactions and drive RAD23A in to an open conformation.
FunctionInvolved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.
FunctionInvolved in vpr-dependent replication of HIV-1 in non- proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.
FunctionMultiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.
InteractionP68104:EEF1A1; NbExp=2; IntAct=EBI-746453, EBI-352162; Q9JI78:Ngly1 (xeno); NbExp=2; IntAct=EBI-746453, EBI-3648128; P55036:PSMD4; NbExp=3; IntAct=EBI-746453, EBI-359318; Q13501:SQSTM1; NbExp=2; IntAct=EBI-746453, EBI-307104; Q9UHD9:UBQLN2; NbExp=3; IntAct=EBI-746453, EBI-947187;
Sequence CautionSequence=BAD92950.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BX448989; Type=Frameshift; Positions=159, 333, 339, 347; Evidence={ECO:0000305};
SimilarityBelongs to the RAD23 family. {ECO:0000305}.
SimilarityContains 1 ubiquitin-like domain. {ECO:0000255|PROSITE-ProRule:PRU00214}.
SimilarityContains 2 UBA domains. {ECO:0000255|PROSITE- ProRule:PRU00212}.
Subcellular LocationNucleus.
SubunitInteracts with XPC; the interaction is suggesting the existence of a functional equivalent variant XPC complex. Interacts with PSMD4 and PSMC5. Interacts with ATXN3. Interacts with HIV-1 vpr. Interacts with UBQLN2. {ECO:0000269|PubMed:10488153, ECO:0000269|PubMed:10915768, ECO:0000269|PubMed:11087358, ECO:0000269|PubMed:12970176, ECO:0000269|PubMed:14557549, ECO:0000269|PubMed:16712842, ECO:0000269|PubMed:17098253, ECO:0000269|PubMed:9371639}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/rad23a/";
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