MGP Database

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MGP002571

Ontology/Pathway Information

Entrez Gene ID5894
Gene NameRaf-1 proto-oncogene, serine/threonine kinase
Gene Symbol RAF1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 ISS:UniProtKBCcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0005794 IPI:MGICGolgi apparatus
GO:0005741 TAS:ProtIncCmitochondrial outer membrane
GO:0005634 IEA:UniProtKB-SubCellCnucleus
GO:0005886 IDA:MGICplasma membrane
GO:0031143 IEA:EnsemblCpseudopodium
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0004709 IEA:EnsemblFMAP kinase kinase kinase activity
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004672 TAS:ProtIncFprotein kinase activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0007190 NAS:BHF-UCLPactivation of adenylate cyclase activity
GO:0000186 IDA:AgBasePactivation of MAPKK activity
GO:0006915 TAS:ProtIncPapoptotic process
GO:0007411 TAS:ReactomePaxon guidance
GO:0007596 TAS:ReactomePblood coagulation
GO:0008283 TAS:ProtIncPcell proliferation
GO:0071550 IEA:EnsemblPdeath-inducing signaling complex assembly
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0007507 IEA:EnsemblPheart development
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0045104 IEA:EnsemblPintermediate filament cytoskeleton organization
GO:0034220 TAS:ReactomePion transmembrane transport
GO:0000165 TAS:ReactomePMAPK cascade
GO:0043066 IDA:UniProtKBPnegative regulation of apoptotic process
GO:0008285 IDA:BHF-UCLPnegative regulation of cell proliferation
GO:0043154 TAS:UniProtKBPnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:1902042 IEA:EnsemblPnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0031333 IDA:UniProtKBPnegative regulation of protein complex assembly
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0030168 TAS:ReactomePplatelet activation
GO:0033138 IDA:UniProtKBPpositive regulation of peptidyl-serine phosphorylation
GO:0006468 TAS:ProtIncPprotein phosphorylation
GO:0007265 TAS:ReactomePRas protein signal transduction
GO:0042981 TAS:UniProtKBPregulation of apoptotic process
GO:0045595 TAS:UniProtKBPregulation of cell differentiation
GO:2000145 TAS:UniProtKBPregulation of cell motility
GO:0035023 TAS:UniProtKBPregulation of Rho protein signal transduction
GO:0001666 IEA:EnsemblPresponse to hypoxia
GO:0007165 TAS:ProtIncPsignal transduction
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
GO:0035019 IEA:EnsemblPsomatic stem cell maintenance
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0055085 TAS:ReactomePtransmembrane transport
GO:0042060 TAS:UniProtKBPwound healing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_75774Adaptive Immune System
REACT_12002ARMS-mediated activation
REACT_18266Axon guidance
REACT_20568CREB phosphorylation through the activation of Ras
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_12076Frs2-mediated activation
REACT_21247FRS2-mediated cascade
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_23847GP1b-IX-V activation signalling
REACT_12606GRB2 events in EGFR signaling
REACT_115854GRB2 events in ERBB2 signaling
REACT_604Hemostasis
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_27283Interleukin-2 signaling
REACT_25300Ion channel transport
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_962MEK activation
REACT_18334NCAM signaling for neurite out-growth
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_798Platelet activation, signaling and aggregation
REACT_20593Post NMDA receptor activation events
REACT_12005Prolonged ERK activation events
REACT_2077RAF activation
REACT_634RAF/MAP kinase cascade
REACT_614RAF phosphorylates MEK
REACT_23898Rap1 signalling
REACT_12579SHC1 events in EGFR signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_116005SHC1 events in ERBB4 signaling
REACT_661SHC-mediated signalling
REACT_999SHC-related events
REACT_150139SHC-related events triggered by IGF1R
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_22232Signaling by Interleukins
REACT_169118Signaling by Leptin
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12077Signalling to p38 via RIT and RIN
REACT_12033Signalling to RAS
REACT_111102Signal Transduction
REACT_524SOS-mediated signalling
REACT_160189Stimuli-sensing channels
REACT_15518Transmembrane transport of small molecules
REACT_13477Transmission across Chemical Synapses
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
SMP00391Insulin Signalling
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