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MGP002574

UniProt Annotations

Entry Information
Gene Nameral guanine nucleotide dissociation stimulator
Protein EntryGNDS_HUMAN
UniProt IDQ12967
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q12967-1; Sequence=Displayed; Name=2; IsoId=Q12967-2; Sequence=VSP_035301; Note=No experimental confirmation available.; Name=3; IsoId=Q12967-3; Sequence=VSP_043659; Name=4; IsoId=Q12967-4; Sequence=VSP_055215, VSP_055217; Note=No experimental confirmation available.; Name=5; IsoId=Q12967-5; Sequence=VSP_055216; Note=No experimental confirmation available. Ref.3 (BAC87018) sequence is in conflict in position: 3:R->W. {ECO:0000305}; Name=6; IsoId=Q12967-6; Sequence=VSP_055217; Note=No experimental confirmation available.;
DomainThe Ras-associating domain interacts with Ras.
FunctionStimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap.
InteractionP01112:HRAS; NbExp=2; IntAct=EBI-365861, EBI-350145; P61224:RAP1B; NbExp=2; IntAct=EBI-365861, EBI-358143;
SimilarityContains 1 N-terminal Ras-GEF domain. {ECO:0000255|PROSITE-ProRule:PRU00135}.
SimilarityContains 1 Ras-associating domain. {ECO:0000255|PROSITE-ProRule:PRU00166}.
SimilarityContains 1 Ras-GEF domain. {ECO:0000255|PROSITE- ProRule:PRU00168}.
SubunitInteracts with RIT1 and RIT2. {ECO:0000250}.
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