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MGP002601

Record overview

MGPD IDMGP002601
Gene ID5950
SpeciesHomo sapiens (Human)
Gene Nameretinol binding protein 4, plasma
Gene Symbol RBP4
SynonymsRDCCAS;
Alternate namesretinol-binding protein 4; PRBP; RBP; plasma retinol-binding protein; retinol-binding protein 4, interstitial;
Chromosome10
Map Location10q23.33
Summary This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for RBP4

Proteins

retinol-binding protein 4 precursor
Refseq ID:NP_006735
Protein GI:55743122
UniProt ID:P02753
mRNA ID:NM_006744
Length:201
RefSeq Status:
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTED
PAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNL
L
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1956
peptide sequence: 
MKWVWALLLLAALGSGRA

mat_peptide: 19..201
product: retinol-binding protein 4
calculated_mol_wt: 21072
peptide sequence: 
ERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKG
NDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
 
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