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MGP002613

Record overview

MGPD IDMGP002613
Gene ID5982
SpeciesHomo sapiens (Human)
Gene Namereplication factor C (activator 1) 2, 40kDa
Gene Symbol RFC2
SynonymsRFC40;
Alternate namesreplication factor C subunit 2; A1 40 kDa subunit; RF-C 40 kDa subunit; activator 1 subunit 2;
Chromosome7
Map Location7q11.23
SummaryThis gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013]
OrthologsView orthologs and multiple alignments for RFC2

Proteins

replication factor C subunit 2 isoform 1
Refseq ID:NP_852136
Protein GI:31563534
UniProt ID:P35250
mRNA ID:NM_181471
Length:354
RefSeq Status:
MEVEAVCGGAGEVEAQDSDPAPAFSKAPGSAGHYELPWVEKYRPVKLNEIVGNEDTVSRLEVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPALKD
AMLELNASNDRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILT
RLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIF
RVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKTMAPVAS
 
replication factor C subunit 2 isoform 2
Refseq ID:NP_002905
Protein GI:28882049
UniProt ID:P35250
mRNA ID:NM_002914
Length:320
RefSeq Status:
MEVEAVCGGAGEVEAQDSDPAPAFSKAPGSAGHYELPWVEKYRPVKLNEIVGNEDTVSRLEVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPALKD
AMLELNASNDSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALN
NLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSL
LQMAGLLARLCQKTMAPVAS
 
replication factor C subunit 2 isoform 3
Refseq ID:NP_001265720
Protein GI:525343582
UniProt ID:P35250
mRNA ID:NM_001278791
Length:253
RefSeq Status:
MLELNASNDRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTR
LMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFR
VCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKTMAPVAS
 
replication factor C subunit 2 isoform 4
Refseq ID:NP_001265721
Protein GI:525343597
UniProt ID:P35250
mRNA ID:NM_001278792
Length:251
RefSeq Status:
MCPTSSLRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLM
NVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVC
KTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKTMAPVAS
 
replication factor C subunit 2 isoform 5
Refseq ID:NP_001265722
Protein GI:525343614
UniProt ID:P35250
mRNA ID:NM_001278793
Length:219
RefSeq Status:
MLELNASNDSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNN
LQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLL
QMAGLLARLCQKTMAPVAS
 
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