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MGP002620

Record overview

MGPD IDMGP002620
Gene ID5999
SpeciesHomo sapiens (Human)
Gene Nameregulator of G-protein signaling 4
Gene Symbol RGS4
SynonymsRGP4; SCZD9;
Alternate namesregulator of G-protein signaling 4; schizophrenia disorder 9;
Chromosome1
Map Location1q23.3
SummaryRegulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for RGS4

Proteins

regulator of G-protein signaling 4 isoform 1
Refseq ID:NP_001095915
Protein GI:156416012
UniProt ID:P49798
mRNA ID:NM_001102445
Length:302
RefSeq Status:
MYNMMLLIQKRKGIGSQLLRAGEAEGDRGAGTAERSSDWLDGRSWAIKETPTGLAGRRSEDSDNIFTGEEAKYAQSRSHSSSCRISFLLANSKLLNKMCK
GLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKS
PSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPSSCGAEKQKGAKSSADCASLVPQ
CA
 
regulator of G-protein signaling 4 isoform 2
Refseq ID:NP_005604
Protein GI:5032039
UniProt ID:P49798
mRNA ID:NM_005613
Length:205
RefSeq Status:
MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKK
IKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPSSCGAEKQKGAKSSADCASL
VPQCA
 
regulator of G-protein signaling 4 isoform 3
Refseq ID:NP_001106851
Protein GI:164664488
UniProt ID:P49798
mRNA ID:NM_001113380
Length:187
RefSeq Status:
MKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEF
ISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPSSCGAEKQKGAKSSADCASLVPQCA
 
regulator of G-protein signaling 4 isoform 4
Refseq ID:NP_001106852
Protein GI:164664490
UniProt ID:P49798
mRNA ID:NM_001113381
Length:93
RefSeq Status:
MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHECEPGFLHQGRDKPEHARAYNNLL
 
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