MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002630

Record overview

MGPD IDMGP002630
Gene ID6016
SpeciesHomo sapiens (Human)
Gene NameRas-like without CAAX 1
Gene Symbol RIT1
SynonymsNS8; RIT; RIBB; ROC1;
Alternate namesGTP-binding protein Rit1; GTP-binding protein Roc1; Ric-like, expressed in many tissues; ras-like protein expressed in many tissues; ras-like without CAAX protein 1;
Chromosome1
Map Location1q22
SummaryThis gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
OrthologsView orthologs and multiple alignments for RIT1

Proteins

GTP-binding protein Rit1 isoform 1
Refseq ID:NP_001243750
Protein GI:378744214
UniProt ID:Q92963
mRNA ID:NM_001256821
Length:236
RefSeq Status:
MERWLFLGATEEGPKRTMDSGTRPVGSCCSSPAGLSREYKLVMLGAGGVGKSAMTMQFISHRFPEDHDPTIEDAYKIRIRIDDEPANLDILDTAGQAEFT
AMRDQYMRAGEGFIICYSITDRRSFHEVREFKQLIYRVRRTDDTPVVLVGNKSDLKQLRQVTKEEGLALAREFSCPFFETSAAYRYYIDDVFHALVREIR
RKEKEAVLAMEKKSKPKNSVWKRLKSPFRKKKDSVT
 
GTP-binding protein Rit1 isoform 2
Refseq ID:NP_008843
Protein GI:5902050
UniProt ID:Q92963
mRNA ID:NM_006912
Length:219
RefSeq Status:
MDSGTRPVGSCCSSPAGLSREYKLVMLGAGGVGKSAMTMQFISHRFPEDHDPTIEDAYKIRIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIICY
SITDRRSFHEVREFKQLIYRVRRTDDTPVVLVGNKSDLKQLRQVTKEEGLALAREFSCPFFETSAAYRYYIDDVFHALVREIRRKEKEAVLAMEKKSKPK
NSVWKRLKSPFRKKKDSVT
 
GTP-binding protein Rit1 isoform 3
Refseq ID:NP_001243749
Protein GI:378744212
UniProt ID:Q92963
mRNA ID:NM_001256820
Length:183
RefSeq Status:
MTMQFISHRFPEDHDPTIEDAYKIRIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIICYSITDRRSFHEVREFKQLIYRVRRTDDTPVVLVGNKS
DLKQLRQVTKEEGLALAREFSCPFFETSAAYRYYIDDVFHALVREIRRKEKEAVLAMEKKSKPKNSVWKRLKSPFRKKKDSVT
 
  logo