MGP Database

MGP002637

Ontology/Pathway Information

Entrez Gene ID	6091
Gene Name	roundabout, axon guidance receptor, homolog 1 (Drosophila)
Gene Symbol	ROBO1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0030673	IEA:Ensembl	C	axolemma
GO:0009986	IDA:UniProtKB	C	cell surface
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0005887	TAS:ProtInc	C	integral component of plasma membrane
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0008046	TAS:ProtInc	F	axon guidance receptor activity
GO:0042802	IDA:UniProtKB	F	identical protein binding
GO:0030275	IPI:UniProtKB	F	LRR domain binding
GO:0006919	IMP:UniProtKB	P	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007411	TAS:Reactome	P	axon guidance
GO:0016199	ISS:UniProtKB	P	axon midline choice point recognition
GO:0007155	TAS:ProtInc	P	cell adhesion
GO:0002042	IMP:BHF-UCL	P	cell migration involved in sprouting angiogenesis
GO:0021836	IDA:UniProtKB	P	chemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0007156	IDA:UniProtKB	P	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0060763	IEA:Ensembl	P	mammary duct terminal end bud growth
GO:0070100	IMP:BHF-UCL	P	negative regulation of chemokine-mediated signaling pathway
GO:0033600	IMP:BHF-UCL	P	negative regulation of mammary gland epithelial cell proliferation
GO:0050925	IDA:UniProtKB	P	negative regulation of negative chemotaxis
GO:0007399	TAS:ProtInc	P	nervous system development
GO:0050772	IDA:UniProtKB	P	positive regulation of axonogenesis
GO:0035385	IMP:BHF-UCL	P	Roundabout signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_19226	Activation of Rac
REACT_18266	Axon guidance
REACT_111045	Developmental Biology
REACT_19342	Inactivation of Cdc42 and Rac
REACT_22237	Netrin-1 signaling
REACT_19376	Regulation of Commissural axon pathfinding by Slit and Robo
REACT_19230	Role of Abl in Robo-Slit signaling
REACT_19351	Signaling by Robo receptor