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MGP002646

UniProt Annotations

Entry Information
Gene Nameribulose-5-phosphate-3-epimerase
Protein EntryRPE_HUMAN
UniProt IDQ96AT9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q96AT9-1; Sequence=Displayed; Name=2; IsoId=Q96AT9-2; Sequence=VSP_008317, VSP_008318; Note=No experimental confirmation available.; Name=3; IsoId=Q96AT9-3; Sequence=VSP_047117, VSP_008318; Note=Gene prediction based on EST data.; Name=4; IsoId=Q96AT9-4; Sequence=VSP_055265; Note=No experimental confirmation available.; Name=5; IsoId=Q96AT9-5; Sequence=VSP_047117; Note=Gene prediction based on EST data.;
Catalytic ActivityD-ribulose 5-phosphate = D-xylulose 5- phosphate. {ECO:0000269|PubMed:20923965}.
CofactorName=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000269|PubMed:20923965}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:20923965}; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:20923965}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000269|PubMed:20923965}; Note=Binds 1 divalent metal cation per subunit. Active with Fe(2+), and probably also with Mn(2+), Zn(2+) and Co(2+). {ECO:0000269|PubMed:20923965};
FunctionCatalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate. {ECO:0000269|PubMed:20923965}.
InteractionSelf; NbExp=2; IntAct=EBI-372480, EBI-372480;
Sequence CautionSequence=BAB71076.1; Type=Frameshift; Positions=69; Evidence={ECO:0000305}; Sequence=BAC04212.1; Type=Frameshift; Positions=42; Evidence={ECO:0000305};
SimilarityBelongs to the ribulose-phosphate 3-epimerase family. {ECO:0000305}.
SubunitHomodimer. {ECO:0000269|Ref.9}.
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