MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002647

Ontology/Pathway Information

Entrez Gene ID6121
Gene Nameretinal pigment epithelium-specific protein 65kDa
Gene Symbol RPE65
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0044297 IEA:EnsemblCcell body
GO:0005783 IEA:UniProtKB-KWCendoplasmic reticulum
GO:0031090 IEA:UniProtKB-SubCellCorganelle membrane
GO:0005886 TAS:ReactomeCplasma membrane
GO:0052885 IEA:UniProtKB-ECFall-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
GO:0052884 IEA:UniProtKB-ECFall-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004744 IEA:EnsemblFretinal isomerase activity
GO:0071257 IEA:EnsemblPcellular response to electrical stimulus
GO:0050908 IMP:UniProtKBPdetection of light stimulus involved in visual perception
GO:0008286 IEA:EnsemblPinsulin receptor signaling pathway
GO:0007603 TAS:ReactomePphototransduction, visible light
GO:0007468 IEA:EnsemblPregulation of rhodopsin gene expression
GO:0001895 IMP:UniProtKBPretina homeostasis
GO:0042574 IEA:EnsemblPretinal metabolic process
GO:0060042 IEA:EnsemblPretina morphogenesis in camera-type eye
GO:0001523 TAS:ReactomePretinoid metabolic process
GO:0007601 TAS:ProtIncPvisual perception
GO:0006776 TAS:ProtIncPvitamin A metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_160102Diseases associated with visual transduction
REACT_111102Signal Transduction
REACT_160156The canonical retinoid cycle in rods (twilight vision)
REACT_160125Visual phototransduction
SMP Pathway Links
SMP IDDescription
SMP00074Retinol Metabolism
SMP00336Vitamin A Deficiency
  logo