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MGP002689

Record overview

MGPD IDMGP002689
Gene ID6182
SpeciesHomo sapiens (Human)
Gene Namemitochondrial ribosomal protein L12
Gene Symbol MRPL12
Synonyms5c5-2; L12mt; MRPL7; RPML12; MRPL7/L12; MRP-L31/34;
Alternate names39S ribosomal protein L12, mitochondrial; MRP-L12;
Chromosome17
Map Location17q25
SummaryMammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for MRPL12

Proteins

39S ribosomal protein L12, mitochondrial
Refseq ID:NP_002940
Protein GI:27436901
UniProt ID:P52815
mRNA ID:NM_002949
Length:198
RefSeq Status:
MLPAAARPLWGPCLGLRAAAFRLARRQVPCVCAVRHMRSSGHQRCEALAGAPLDNAPKEYPPKIQQLVQDIASLTLLEISDLNELLKKTLKIQDVGLVPM
GGVMSGAVPAAAAQEAVEEDIPIAKERTHFTVRLTEAKPVDKVKLIKEIKNYIQGINLVQAKKLVESLPQEIKANVAKAEAEKIKAALEAVGGTVVLE
 
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