MGP Database

MGP002730

Ontology/Pathway Information

Entrez Gene ID6240
Gene Nameribonucleotide reductase M1
Gene Symbol RRM1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0042995 IEA:EnsemblCcell projection
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0005635 IEA:EnsemblCnuclear envelope
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004748 ISS:UniProtKBFribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0021846 IEA:EnsemblPcell proliferation in forebrain
GO:0009263 ISS:UniProtKBPdeoxyribonucleotide biosynthetic process
GO:0006260 IEA:UniProtKB-UniPathwayPDNA replication
GO:0008584 IEA:EnsemblPmale gonad development
GO:0000278 IEA:EnsemblPmitotic cell cycle
GO:0015949 TAS:ReactomePnucleobase-containing small molecule interconversion
GO:0055086 TAS:ReactomePnucleobase-containing small molecule metabolic process
GO:0051290 IEA:EnsemblPprotein heterotetramerization
GO:0006206 IEA:EnsemblPpyrimidine nucleobase metabolic process
GO:0010212 IEA:EnsemblPresponse to ionizing radiation
GO:0060041 IEA:EnsemblPretina development in camera-type eye
GO:0044281 TAS:ReactomePsmall molecule metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111217Metabolism
REACT_1698Metabolism of nucleotides
REACT_21330Synthesis and interconversion of nucleotide di- and triphosphates
SMP Pathway Links
SMP IDDescription
SMP00535Adenine phosphoribosyltransferase deficiency (APRT)
SMP00144Adenosine Deaminase Deficiency
SMP00167Adenylosuccinate Lyase Deficiency
SMP00168AICA-Ribosiduria
SMP00427Azathioprine Action Pathway
SMP00446Gemcitabine Action Pathway
SMP00603Gemcitabine Metabolism Pathway
SMP00365Gout or Kelley-Seegmiller Syndrome
SMP00364Lesch-Nyhan Syndrome (LNS)
SMP00428Mercaptopurine Action Pathway
SMP00536Mitochondrial DNA depletion syndrome
SMP00203Molybdenum Cofactor Deficiency
SMP00537Myoadenylate deaminase deficiency
SMP00050Purine Metabolism
SMP00210Purine Nucleoside Phosphorylase Deficiency
SMP00430Thioguanine Action Pathway
SMP00220Xanthine Dehydrogenase Deficiency (Xanthinuria)
SMP00512Xanthinuria type I
SMP00513Xanthinuria type II
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