MGP Database

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MGP002734

Ontology/Pathway Information

Entrez Gene ID6256
Gene Nameretinoid X receptor, alpha
Gene Symbol RXRA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0000790 IDA:BHF-UCLCnuclear chromatin
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0043235 IDA:BHF-UCLCreceptor complex
GO:0090575 IDA:BHF-UCLCRNA polymerase II transcription factor complex
GO:0004886 TAS:ProtIncF9-cis retinoic acid receptor activity
GO:0031490 IEA:EnsemblFchromatin DNA binding
GO:0003677 IDA:MGIFDNA binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0004879 IDA:BHF-UCLFligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0046982 IDA:UniProtKBFprotein heterodimerization activity
GO:0003708 TAS:BHF-UCLFretinoic acid receptor activity
GO:0044323 IDA:UniProtKBFretinoic acid-responsive element binding
GO:0000977 IDA:MGIFRNA polymerase II regulatory region sequence-specific DNA binding
GO:0043565 IDA:AgBaseFsequence-specific DNA binding
GO:0003700 IDA:UniProtKBFsequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterProFsteroid hormone receptor activity
GO:0003713 TAS:ProtIncFtranscription coactivator activity
GO:0042809 IPI:BHF-UCLFvitamin D receptor binding
GO:0008270 IEA:InterProFzinc ion binding
GO:0043010 IEA:EnsemblPcamera-type eye development
GO:0060038 IEA:EnsemblPcardiac muscle cell proliferation
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0008203 TAS:BHF-UCLPcholesterol metabolic process
GO:0007566 IEA:EnsemblPembryo implantation
GO:0010467 TAS:ReactomePgene expression
GO:0001701 IEA:EnsemblPin utero embryonic development
GO:0001893 IEA:EnsemblPmaternal placenta development
GO:0019048 IDA:UniProtKBPmodulation by virus of host morphology or physiology
GO:0000122 IDA:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0035357 IDA:UniProtKBPperoxisome proliferator activated receptor signaling pathway
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0051289 IDA:MGIPprotein homotetramerization
GO:0060687 IEA:EnsemblPregulation of branching involved in prostate gland morphogenesis
GO:0032526 IMP:BHF-UCLPresponse to retinoic acid
GO:0048384 IMP:BHF-UCLPretinoic acid receptor signaling pathway
GO:0060528 IEA:EnsemblPsecretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0055012 IEA:EnsemblPventricular cardiac muscle cell differentiation
GO:0055010 IEA:EnsemblPventricular cardiac muscle tissue morphogenesis
GO:0006766 TAS:ProtIncPvitamin metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147904Activation of gene expression by SREBF (SREBP)
REACT_11040Bile acid and bile salt metabolism
REACT_13433Biological oxidations
REACT_111118BMAL1:CLOCK,NPAS2 activates circadian gene expression
REACT_24941Circadian Clock
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_111045Developmental Biology
REACT_116125Disease
REACT_13812Endogenous sterols
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_11082Import of palmitoyl-CoA into the mitochondrial matrix
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_264351Mitochondrial biogenesis
REACT_15525Nuclear Receptor transcription pathway
REACT_264135Organelle biogenesis and maintenance
REACT_268444Orphan transporters
REACT_13705Phase 1 - Functionalization of compounds
REACT_116145PPARA activates gene expression
REACT_2071Pyruvate metabolism
REACT_1046Pyruvate metabolism and Citric Acid (TCA) cycle
REACT_11042Recycling of bile acids and salts
REACT_147797Regulation of cholesterol biosynthesis by SREBP (SREBF)
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_12528Regulation of pyruvate dehydrogenase (PDH) complex
REACT_118789REV-ERBA represses gene expression
REACT_118659RORA activates circadian gene expression
REACT_267785Signaling by Retinoic Acid
REACT_111102Signal Transduction
REACT_11054Synthesis of bile acids and bile salts
REACT_11048Synthesis of bile acids and bile salts via 27-hydroxycholesterol
REACT_11041Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
REACT_111083The citric acid (TCA) cycle and respiratory electron transport
REACT_264212Transcriptional activation of mitochondrial biogenesis
REACT_27161Transcriptional regulation of white adipocyte differentiation
REACT_15518Transmembrane transport of small molecules
REACT_118713YAP1- and WWTR1 (TAZ)-stimulated gene expression
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