MGP Database

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MGP002739

Ontology/Pathway Information

Entrez Gene ID6262
Gene Nameryanodine receptor 2 (cardiac)
Gene Symbol RYR2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0034704 IDA:BHF-UCLCcalcium channel complex
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0014701 TAS:BHF-UCLCjunctional sarcoplasmic reticulum membrane
GO:0016020 IDA:BHF-UCLCmembrane
GO:0005886 ISS:BHF-UCLCplasma membrane
GO:0043234 IDA:MGICprotein complex
GO:0016529 IDA:BHF-UCLCsarcoplasmic reticulum
GO:0033017 ISS:BHF-UCLCsarcoplasmic reticulum membrane
GO:0005790 IEA:EnsemblCsmooth endoplasmic reticulum
GO:0030018 ISS:BHF-UCLCZ disc
GO:0005262 ISS:UniProtKBFcalcium channel activity
GO:0048763 IDA:BHF-UCLFcalcium-induced calcium release activity
GO:0005509 IEA:InterProFcalcium ion binding
GO:0015278 IDA:BHF-UCLFcalcium-release channel activity
GO:0005516 IMP:BHF-UCLFcalmodulin binding
GO:0019899 IPI:BHF-UCLFenzyme binding
GO:0042802 IPI:BHF-UCLFidentical protein binding
GO:0005218 ISS:UniProtKBFintracellular ligand-gated calcium channel activity
GO:0044325 ISS:BHF-UCLFion channel binding
GO:0034236 IDA:BHF-UCLFprotein kinase A catalytic subunit binding
GO:0034237 IDA:BHF-UCLFprotein kinase A regulatory subunit binding
GO:0005219 IDA:BHF-UCLFryanodine-sensitive calcium-release channel activity
GO:0043924 IMP:BHF-UCLFsuramin binding
GO:0030509 IEA:EnsemblPBMP signaling pathway
GO:0006816 IDA:BHF-UCLPcalcium ion transport
GO:0060402 IDA:BHF-UCLPcalcium ion transport into cytosol
GO:0019722 ISS:UniProtKBPcalcium-mediated signaling
GO:0035584 IDA:BHF-UCLPcalcium-mediated signaling using intracellular calcium source
GO:0060070 IEA:EnsemblPcanonical Wnt signaling pathway
GO:0060048 IMP:BHF-UCLPcardiac muscle contraction
GO:0003300 ISS:BHF-UCLPcardiac muscle hypertrophy
GO:0086064 IC:BHF-UCLPcell communication by electrical coupling involved in cardiac conduction
GO:0006874 ISS:UniProtKBPcellular calcium ion homeostasis
GO:0071313 ISS:UniProtKBPcellular response to caffeine
GO:0071872 TAS:BHF-UCLPcellular response to epinephrine stimulus
GO:0051480 ISS:BHF-UCLPcytosolic calcium ion homeostasis
GO:0005513 IDA:BHF-UCLPdetection of calcium ion
GO:0003143 ISS:UniProtKBPembryonic heart tube morphogenesis
GO:0072599 IDA:BHF-UCLPestablishment of protein localization to endoplasmic reticulum
GO:0034220 TAS:ReactomePion transmembrane transport
GO:0003220 ISS:BHF-UCLPleft ventricular cardiac muscle tissue morphogenesis
GO:1901896 IDA:BHF-UCLPpositive regulation of calcium-transporting ATPase activity
GO:0010460 ISS:BHF-UCLPpositive regulation of heart rate
GO:0086094 ISS:BHF-UCLPpositive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction
GO:0051284 IDA:BHF-UCLPpositive regulation of sequestering of calcium ion
GO:0098735 IMP:BHF-UCLPpositive regulation of the force of heart contraction
GO:0086029 ISS:BHF-UCLPPurkinje myocyte to ventricular cardiac muscle cell signaling
GO:0055117 IMP:BHF-UCLPregulation of cardiac muscle contraction
GO:0010881 ISS:BHF-UCLPregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0002027 IMP:BHF-UCLPregulation of heart rate
GO:0051209 IDA:BHF-UCLPrelease of sequestered calcium ion into cytosol
GO:0014808 IMP:BHF-UCLPrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0031000 IDA:BHF-UCLPresponse to caffeine
GO:0001666 ISS:BHF-UCLPresponse to hypoxia
GO:0035994 IMP:BHF-UCLPresponse to muscle stretch
GO:0051775 IDA:BHF-UCLPresponse to redox state
GO:0070296 TAS:BHF-UCLPsarcoplasmic reticulum calcium ion transport
GO:0055085 TAS:ReactomePtransmembrane transport
GO:0097050 IMP:BHF-UCLPtype B pancreatic cell apoptotic process
GO:0086005 ISS:BHF-UCLPventricular cardiac muscle cell action potential
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_25300Ion channel transport
REACT_160189Stimuli-sensing channels
REACT_15518Transmembrane transport of small molecules
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00331Flecainide Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00332Ibutilide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00323Quinidine Action Pathway
SMP00660Sotalol Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00375Verapamil Action Pathway
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