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MGP002748

UniProt Annotations

Entry Information
Gene Nameseryl-tRNA synthetase
Protein EntrySYSC_HUMAN
UniProt IDP49591
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).
Catalytic ActivityATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
DomainConsists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding. {ECO:0000250}.
FunctionCatalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). {ECO:0000269|PubMed:9431993}.
PathwayAminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.
SimilarityBelongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. The tRNA molecule binds across the dimer (By similarity). {ECO:0000250}.
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