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MGP002749

Record overview

MGPD IDMGP002749
Gene ID6303
SpeciesHomo sapiens (Human)
Gene Namespermidine/spermine N1-acetyltransferase 1
Gene Symbol SAT1
SynonymsSAT; DC21; KFSD; SSAT; KFSDX; SSAT-1;
Alternate namesdiamine acetyltransferase 1; diamine N-acetyltransferase 1; polyamine N-acetyltransferase 1; putrescine acetyltransferase; spermidine/spermine N1-acetyltransferase alpha;
ChromosomeX
Map LocationXp22.1
EC Number2.3.1.57
SummaryThe protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]
OrthologsView orthologs and multiple alignments for SAT1

Proteins

diamine acetyltransferase 1
Refseq ID:NP_002961
Protein GI:4506789
UniProt ID:P21673
mRNA ID:NM_002970
Length:171
RefSeq Status:
MAKFVIRPATAADCSDILRLIKELAKYEYMEEQVILTEKDLLEDGFGEHPFYHCLVAEVPKEHWTPEGHSIVGFAMYYFTYDPWIGKLLYLEDFFVMSDY
RGFGIGSEILKNLSQVAMRCRCSSMHFLVAEWNEPSINFYKRRGASDLSSEEGWRLFKIDKEYLLKMATEE
 
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