MGP Database

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MGP002758

UniProt Annotations

Entry Information
Gene Namesodium channel, voltage gated, type III alpha subunit
Protein EntrySCN3A_HUMAN
UniProt IDQ9NY46
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Comment=Exons 6A and 6N only differ by a single residue.; Name=1; Synonyms=6A-12+12b; IsoId=Q9NY46-1; Sequence=Displayed; Name=2; Synonyms=6A-12; IsoId=Q9NY46-2; Sequence=VSP_001034; Name=3; Synonyms=6N-12+12b; IsoId=Q9NY46-3; Sequence=VSP_001033; Name=4; Synonyms=6N-12; IsoId=Q9NY46-4; Sequence=VSP_001033, VSP_001034;
DomainThe sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
FunctionMediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
PtmMay be ubiquitinated by NEDD4L; which would promote its endocytosis.
PtmPhosphorylation at Ser-1501 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. {ECO:0000250}.
SimilarityBelongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily. {ECO:0000305}.
SimilarityContains 1 IQ domain. {ECO:0000255|PROSITE- ProRule:PRU00116}.
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitThe sodium channel consists of a large polypeptide and 2- 3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4L. {ECO:0000269|PubMed:15548568}.
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