MGP Database

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MGP002761

Ontology/Pathway Information

Entrez Gene ID6331
Gene Namesodium channel, voltage gated, type V alpha subunit
Gene Symbol SCN5A
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005901 IDA:BHF-UCLCcaveola
GO:0009986 IDA:BHF-UCLCcell surface
GO:0005783 IDA:BHF-UCLCendoplasmic reticulum
GO:0016021 IDA:UniProtKBCintegral component of membrane
GO:0014704 IDA:BHF-UCLCintercalated disc
GO:0016328 TAS:BHF-UCLClateral plasma membrane
GO:0005886 IDA:BHF-UCLCplasma membrane
GO:0042383 IDA:BHF-UCLCsarcolemma
GO:0030315 IDA:BHF-UCLCT-tubule
GO:0001518 IDA:BHF-UCLCvoltage-gated sodium channel complex
GO:0030506 IDA:BHF-UCLFankyrin binding
GO:0005516 IPI:BHF-UCLFcalmodulin binding
GO:0019899 IPI:BHF-UCLFenzyme binding
GO:0017134 IPI:BHF-UCLFfibroblast growth factor binding
GO:0044325 IPI:BHF-UCLFion channel binding
GO:0050998 IPI:BHF-UCLFnitric-oxide synthase binding
GO:0019901 IPI:BHF-UCLFprotein kinase binding
GO:0097110 IPI:BHF-UCLFscaffold protein binding
GO:0031625 IPI:BHF-UCLFubiquitin protein ligase binding
GO:0005248 IDA:UniProtKBFvoltage-gated sodium channel activity
GO:0086006 IDA:BHF-UCLFvoltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086067 IMP:BHF-UCLPAV node cell to bundle of His cell communication
GO:0003360 ISS:BHF-UCLPbrainstem development
GO:0086069 IMP:BHF-UCLPbundle of His cell to Purkinje myocyte communication
GO:0086002 IMP:BHF-UCLPcardiac muscle cell action potential involved in contraction
GO:0060048 IMP:BHF-UCLPcardiac muscle contraction
GO:0003231 ISS:BHF-UCLPcardiac ventricle development
GO:0071277 IDA:UniProtKBPcellular response to calcium ion
GO:0021549 ISS:BHF-UCLPcerebellum development
GO:0051899 IDA:BHF-UCLPmembrane depolarization
GO:0086010 IDA:BHF-UCLPmembrane depolarization during action potential
GO:0086012 IMP:BHF-UCLPmembrane depolarization during cardiac muscle cell action potential
GO:0086046 ISS:BHF-UCLPmembrane depolarization during SA node cell action potential
GO:0019228 IBA:GO_CentralPneuronal action potential
GO:0042475 ISS:BHF-UCLPodontogenesis of dentin-containing tooth
GO:0045760 ISS:BHF-UCLPpositive regulation of action potential
GO:0050679 ISS:BHF-UCLPpositive regulation of epithelial cell proliferation
GO:0010765 IDA:BHF-UCLPpositive regulation of sodium ion transport
GO:0060371 IMP:BHF-UCLPregulation of atrial cardiac muscle cell membrane depolarization
GO:0060372 IMP:BHF-UCLPregulation of atrial cardiac muscle cell membrane repolarization
GO:0086004 IMP:BHF-UCLPregulation of cardiac muscle cell contraction
GO:0002027 IMP:BHF-UCLPregulation of heart rate
GO:0086091 IMP:BHF-UCLPregulation of heart rate by cardiac conduction
GO:1902305 IDA:BHF-UCLPregulation of sodium ion transmembrane transport
GO:0060373 IMP:BHF-UCLPregulation of ventricular cardiac muscle cell membrane depolarization
GO:0060307 IMP:BHF-UCLPregulation of ventricular cardiac muscle cell membrane repolarization
GO:0014894 ISS:BHF-UCLPresponse to denervation involved in regulation of muscle adaptation
GO:0086070 IMP:BHF-UCLPSA node cell to atrial cardiac muscle cell communication
GO:0035725 IDA:BHF-UCLPsodium ion transmembrane transport
GO:0006814 IDA:UniProtKBPsodium ion transport
GO:0021537 ISS:BHF-UCLPtelencephalon development
GO:0086005 IMP:BHF-UCLPventricular cardiac muscle cell action potential
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18266Axon guidance
REACT_111045Developmental Biology
REACT_22266Interaction between L1 and Ankyrins
REACT_22205L1CAM interactions
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00331Flecainide Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00618Fosphenytoin (Antiarrhythmic) Metabolism Pathway
SMP00332Ibutilide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00323Quinidine Action Pathway
SMP00660Sotalol Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00375Verapamil Action Pathway
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