MGP Database

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MGP002762

UniProt Annotations

Entry Information
Gene Namesodium channel, voltage gated, type VII alpha subunit
Protein EntrySCN7A_HUMAN
UniProt IDQ01118
SpeciesHuman
Comments
Comment typeDescription
DomainThe sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
FunctionMediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
SimilarityBelongs to the sodium channel (TC 1.A.1.10) family. SCN7A subfamily. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
Tissue SpecificityHeart and uterus.
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