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MGP002767

Record overview

MGPD IDMGP002767
Gene ID6338
SpeciesHomo sapiens (Human)
Gene Namesodium channel, non voltage gated 1 beta subunit
Gene Symbol SCNN1B
SynonymsBESC1; ENaCb; SCNEB; ENaCbeta;
Alternate namesamiloride-sensitive sodium channel subunit beta; amiloride-sensitive sodium channel subunit beta 1; beta-ENaC; beta-NaCH; epithelial Na(+) channel subunit beta; epithelial sodium channel beta-2 subunit; epithelial sodium channel beta-3 subunit; nasal epithelial sodium channel beta subunit; nonvoltage-gated sodium channel 1 subunit beta; sodium channel, non-voltage-gated 1, beta subunit; sodium channel, nonvoltage-gated 1, beta;
Chromosome16
Map Location16p12.2-p12.1
SummaryNonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. [provided by RefSeq, Apr 2009]
OrthologsView orthologs and multiple alignments for SCNN1B

Proteins

amiloride-sensitive sodium channel subunit beta
Refseq ID:NP_000327
Protein GI:124301196
UniProt ID:P51168
mRNA ID:NM_000336
Length:640
RefSeq Status:
MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNA
SPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNR
TQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILD
IGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCN
CGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQ
EFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPN
TGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
 
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