MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002768

UniProt Annotations

Entry Information
Gene Namesodium channel, non voltage gated 1 delta subunit
Protein EntrySCNND_HUMAN
UniProt IDP51172
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=delta1; IsoId=P51172-1; Sequence=Displayed; Name=2; Synonyms=delta2; IsoId=P51172-2; Sequence=VSP_007725; Note=Channels including isoform 2 exhibit greater conductance than those containing isoform 1. Ref.2 (ABI64069) sequence is in conflict in position: 78:T->A. {ECO:0000305};
FunctionSodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
InteractionQ8N668:COMMD1; NbExp=3; IntAct=EBI-2547114, EBI-1550112;
SimilarityBelongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1D subfamily. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:19520916}; Multi-pass membrane protein {ECO:0000269|PubMed:19520916}.
SubunitProbable heterotrimer containing one alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. {ECO:0000269|PubMed:16423824}.
  logo