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MGP002793

Record overview

MGPD IDMGP002793
Gene ID6383
SpeciesHomo sapiens (Human)
Gene Namesyndecan 2
Gene Symbol SDC2
SynonymsHSPG; CD362; HSPG1; SYND2;
Alternate namessyndecan-2; cell surface-associated heparan sulfate proteoglycan 1; fibroglycan; heparan sulfate proteoglycan 1, cell surface-associated; heparan sulfate proteoglycan core protein; syndecan proteoglycan 2;
Chromosome8
Map Location8q22-q23
SummaryThe protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SDC2

Proteins

syndecan-2 precursor
Refseq ID:NP_002989
Protein GI:40548378
UniProt ID:P34741
mRNA ID:NM_002998
Length:201
RefSeq Status:
MRRAWILLTLGLVACVSAESRAELTSDKDMYLDNSSIEEASGVYPIDDDDYASASGSGADEDVESPELTTSRPLPKILLTSAAPKVETTTLNIQNKIPAQ
TKSPEETDKEKVHLSDSERKMDPAEEDTNVYTEKHSDSLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFY
A
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1973
peptide sequence: 
MRRAWILLTLGLVACVSA

mat_peptide: 19..201
product: syndecan-2
calculated_mol_wt: 20205
peptide sequence: 
ESRAELTSDKDMYLDNSSIEEASGVYPIDDDDYASASGSGADEDVESPELTTSRPLPKILLTSAAPKVETTTLNIQNKIPAQTKSPEETDKEKVHLSDSE
RKMDPAEEDTNVYTEKHSDSLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA
 
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