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MGP002794

UniProt Annotations

Entry Information
Gene Namesyndecan 4
Protein EntrySDC4_HUMAN
UniProt IDP31431
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P31431-1; Sequence=Displayed; Name=2; IsoId=P31431-2; Sequence=VSP_044449; Note=Soluble form, lacks the transmembrane domain.;
FunctionCell surface proteoglycan that bears heparan sulfate.
InteractionP17252:PRKCA; NbExp=2; IntAct=EBI-3913237, EBI-1383528;
PtmShedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
SimilarityBelongs to the syndecan proteoglycan family. {ECO:0000305}.
Subcellular LocationIsoform 1: Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000250}.
Subcellular LocationIsoform 2: Secreted.
SubunitHomodimer. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1 (By similarity). Interacts with CDCP1 and SDCBP. {ECO:0000250, ECO:0000269|PubMed:12842047, ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:16533050}.
Tissue SpecificityExpressed in epithelial and fibroblastic cells. {ECO:0000269|PubMed:1500433}.
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