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MGP002798

Record overview

MGPD IDMGP002798
Gene ID6390
SpeciesHomo sapiens (Human)
Gene Namesuccinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene Symbol SDHB
SynonymsIP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP;
Alternate namessuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; iron-sulfur subunit of complex II;
Chromosome1
Map Location1p36.1-p35
EC Number1.3.5.1
SummaryComplex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SDHB

Proteins

succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor
Refseq ID:NP_002991
Protein GI:115387094
UniProt ID:P21912
mRNA ID:NM_003000
Length:280
RefSeq Status:
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGS
CAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYW
WNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
 
transit_peptide: 1..28
calculated_mol_wt: 2840
peptide sequence: 
MAAVVALSLRRRLPATTLGGACLQASRG

mat_peptide: 29..280
product: succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
calculated_mol_wt: 28808
peptide sequence: 
AQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIY
PLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTE
ERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
 
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