MGP Database

MGP002799

Record overview

MGPD ID	MGP002799
Gene ID	6391
Species	Homo sapiens (Human)
Gene Name	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
Gene Symbol	SDHC
Synonyms	CYBL; PGL3; QPS1; SDH3; CYB560;
Alternate names	succinate dehydrogenase cytochrome b560 subunit, mitochondrial; cytochrome B large subunit of complex II; integral membrane protein CII-3b; succinate dehydrgenase cytochrome b; succinate dehydrogenase 3, integral membrane subunit; succinate dehydrogenase complex, subunit C, integral membrane protein, 15kD; succinate-ubiquinone oxidoreductase cytochrome B large subunit;
Chromosome	1
Map Location	1q23.3
Summary	This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]
Orthologs	View orthologs and multiple alignments for SDHC

Proteins

succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 1 precursor

Refseq ID:	NP_002992
Protein GI:	4506863
UniProt ID:	Q99643
mRNA ID:	NM_003001
Length:	169
RefSeq Status:

`MAALLLRHVGRHCLRAHFSPQLCIRNAVPLGTTAKEEMERFWNKNIGSNRPLSPHITIYSWSLPMAMSICHRGTGIALSAGVSLFGMSALLLPGNFESYL ELVKSLCLGPALIHTAKFALVFPLMYHTWNGIRHLMWDLGKGLKIPQLYQSGVVVLVLTVLSSMGLAAM`

transit_peptide: 1..29
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q99643.1)
calculated_mol_wt: 3281
peptide sequence: 
MAALLLRHVGRHCLRAHFSPQLCIRNAVP

mat_peptide: 30..169
product: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q99643.1)
calculated_mol_wt: 15347
peptide sequence: 
LGTTAKEEMERFWNKNIGSNRPLSPHITIYSWSLPMAMSICHRGTGIALSAGVSLFGMSALLLPGNFESYLELVKSLCLGPALIHTAKFALVFPLMYHTW
NGIRHLMWDLGKGLKIPQLYQSGVVVLVLTVLSSMGLAAM

succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 2 precursor

Refseq ID:	NP_001030588
Protein GI:	78711820
UniProt ID:	Q99643
mRNA ID:	NM_001035511
Length:	150
RefSeq Status:

succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 3 precursor
`MAALLLRHVGRHCLRAHFSPQLCIRNAVPLGTTAKEEMERFWNKNIGSNRPLSPHITIYSWSLPMAMSICHRGTGIALSADVGPRKRPEDSPAIPVWSGC PGSYCVVLYGAGSHVKKGGSQHHLPTHYYIHPSFCLSFLSPAWEKFSLFV`

Refseq ID:	NP_001030589
Protein GI:	78711822
UniProt ID:	Q99643
mRNA ID:	NM_001035512
Length:	135
RefSeq Status:

succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 4 precursor
`MAALLLRHVGRHCLRAHFSPQLCIRNWSLPMAMSICHRGTGIALSAGVSLFGMSALLLPGNFESYLELVKSLCLGPALIHTAKFALVFPLMYHTWNGIRH LMWDLGKGLKIPQLYQSGVVVLVLTVLSSMGLAAM`

Refseq ID:	NP_001030590
Protein GI:	78711824
UniProt ID:	Q99643
mRNA ID:	NM_001035513
Length:	116
RefSeq Status:

succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 5 precursor
`MAALLLSWSLPMAMSICHRGTGIALSAGVSLFGMSALLLPGNFESYLELVKSLCLGPALIHTAKFALVFPLMYHTWNGIRHLMWDLGKGLKIPQLYQSGV VVLVLTVLSSMGLAAM`

Refseq ID:	NP_001265101
Protein GI:	498917305
UniProt ID:	Q99643
mRNA ID:	NM_001278172
Length:	116
RefSeq Status:

`MAALLLRHVGRHCLRAHFSPQLCIRNWSLPMAMSICHRGTGIALSADVGPRKRPEDSPAIPVWSGCPGSYCVVLYGAGSHVKKGGSQHHLPTHYYIHPSF CLSFLSPAWEKFSLFV`