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MGP002800

Record overview

MGPD IDMGP002800
Gene ID6392
SpeciesHomo sapiens (Human)
Gene Namesuccinate dehydrogenase complex, subunit D, integral membrane protein
Gene Symbol SDHD
SynonymsPGL; CBT1; CWS3; PGL1; QPs3; SDH4; cybS; CII-4;
Alternate namessuccinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; succinate-ubiquinone oxidoreductase cytochrome b small subunit; succinate-ubiquinone reductase membrane anchor subunit;
Chromosome11
Map Location11q23
SummaryThis gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
OrthologsView orthologs and multiple alignments for SDHD

Proteins

succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform a precursor
Refseq ID:NP_002993
Protein GI:4506865
UniProt ID:O14521
mRNA ID:NM_003002
Length:159
RefSeq Status:
MAVLWRLSAVCGALGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPSHHSGSKAASLHWTSERVVSVLLLGLLPAAYLNPCSAMDYSLAAALT
LHGHWGLGQVVTDYVHGDALQKAAKAGLLALSALTFAGLCYFNYHDVGICKAVAMLWKL
 
transit_peptide: 1..56
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (O14521.1)
calculated_mol_wt: 6172
peptide sequence: 
MAVLWRLSAVCGALGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPSHH

mat_peptide: 57..159
product: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O14521.1)
calculated_mol_wt: 10889
peptide sequence: 
SGSKAASLHWTSERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGLGQVVTDYVHGDALQKAAKAGLLALSALTFAGLCYFNYHDVGICKAVAML
WKL
 
succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform b precursor
Refseq ID:NP_001263432
Protein GI:452405465
UniProt ID:O14521
mRNA ID:NM_001276503
Length:85
RefSeq Status:
MAVLWRLSAVCGALGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPSHHWALDKLLLTMFMGMPCRKLPRQGFWHFQL
 
succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform c precursor
Refseq ID:NP_001263433
Protein GI:452405678
UniProt ID:O14521
mRNA ID:NM_001276504
Length:120
RefSeq Status:
MAVLWRLSAVCGALGGRAGSKAASLHWTSERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGLGQVVTDYVHGDALQKAAKAGLLALSALTFAGL
CYFNYHDVGICKAVAMLWKL
 
succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform d precursor
Refseq ID:NP_001263435
Protein GI:452406068
UniProt ID:O14521
mRNA ID:NM_001276506
Length:143
RefSeq Status:
MAVLWRLSAVCGALGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPSHHSGSKAASLHWTSERVVSVLLLGLLPAAYLNPCSAMDYSLAAALT
LHGHWLECNGAILARHDLGSARSQLTATSAFRVQAILLPQPPK
 
transit_peptide: 1..56
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (O14521.1)
calculated_mol_wt: 6172
peptide sequence: 
MAVLWRLSAVCGALGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPSHH

mat_peptide: 57..159
product: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O14521.1)
calculated_mol_wt: 10889
peptide sequence: 
SGSKAASLHWTSERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGLGQVVTDYVHGDALQKAAKAGLLALSALTFAGLCYFNYHDVGICKAVAML
WKL

transit_peptide: 1..56
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (O14521.1)
calculated_mol_wt: 6172
peptide sequence: 
MAVLWRLSAVCGALGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPSHH
 
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