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MGP002803

UniProt Annotations

Entry Information
Gene Nameselectin E
Protein EntryLYAM2_HUMAN
UniProt IDP16581
SpeciesHuman
Comments
Comment typeDescription
FunctionCell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. {ECO:0000269|PubMed:1689848}.
PolymorphismA polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).
SimilarityBelongs to the selectin/LECAM family. {ECO:0000305}.
SimilarityContains 1 C-type lectin domain. {ECO:0000255|PROSITE- ProRule:PRU00040}.
SimilarityContains 1 EGF-like domain. {ECO:0000255|PROSITE- ProRule:PRU00076}.
SimilarityContains 6 Sushi (CCP/SCR) domains. {ECO:0000255|PROSITE-ProRule:PRU00302}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitInteracts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction. {ECO:0000269|PubMed:11081633, ECO:0000269|PubMed:18606703}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SELEID42247ch1q22.html";
Web ResourceName=Functional Glycomics Gateway - Glycan Binding; Note=E-selectin; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_233";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/sele/";
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