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MGP002823

UniProt Annotations

Entry Information
Gene NameSrc homology 2 domain containing adaptor protein B
Protein EntrySHB_HUMAN
UniProt IDQ15464
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15464-1; Sequence=Displayed; Name=2; IsoId=Q15464-2; Sequence=VSP_019846, VSP_019847; Note=No experimental confirmation available.;
DomainThe SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.
FunctionAdapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}.
InteractionP00519:ABL1; NbExp=5; IntAct=EBI-4402156, EBI-375543; P10721:KIT; NbExp=2; IntAct=EBI-4402156, EBI-1379503; P08581:MET; NbExp=4; IntAct=EBI-4402156, EBI-1039152;
PtmPhosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation. {ECO:0000269|PubMed:10488157, ECO:0000269|PubMed:18220336, ECO:0000269|PubMed:18669648}.
Sequence CautionSequence=AAH94765.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA53091.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subcellular LocationCytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.
SubunitInteracts with PTPN11 (By similarity). Interacts with phosphorylated 'Tyr-720' of the ligand-activated receptor PDGFRA via its SH2 domain. Interacts with the ligand-activated receptors PDGFRB, FGFR1, KDR/VEGFR2, IL2RB and IL2RG. Interacts with EPS8 and V-SRC. Interacts with GRB2 and GRAP. Interacts with CD3Z. Interacts with tyrosine-phosphorylated LAT upon T-cell antigen receptor activation. Interacts with PLCG1. Interacts with ZAP70, LCP2/SLP-76, VAV1 and GRAP2. Interacts with JAK1 and JAK3. Interacts with PTK2/FAK1. Interacts with CRK/CrKII. Interacts with IRS2. {ECO:0000250, ECO:0000269|PubMed:10488157, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:10964504, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:12200137, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:7537362, ECO:0000269|PubMed:8302579, ECO:0000269|PubMed:9484780}.
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:9484780}.
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