MGP Database

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MGP002824

Ontology/Pathway Information

Entrez Gene ID6464
Gene NameSHC (Src homology 2 domain containing) transforming protein 1
Gene Symbol SHC1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005759 IEA:UniProtKB-SubCellCmitochondrial matrix
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0070435 ISS:BHF-UCLCShc-EGFR complex
GO:0046875 IPI:UniProtKBFephrin receptor binding
GO:0005154 ISS:BHF-UCLFepidermal growth factor receptor binding
GO:0005159 IPI:UniProtKBFinsulin-like growth factor receptor binding
GO:0005158 IPI:UniProtKBFinsulin receptor binding
GO:0005168 IPI:UniProtKBFneurotrophin TRKA receptor binding
GO:0005543 TAS:UniProtKBFphospholipid binding
GO:0019901 IBA:GO_CentralFprotein kinase binding
GO:0004713 TAS:ReactomeFprotein tyrosine kinase activity
GO:0005068 TAS:UniProtKBFtransmembrane receptor protein tyrosine kinase adaptor activity
GO:0031532 IEA:EnsemblPactin cytoskeleton reorganization
GO:0000187 IDA:UniProtKBPactivation of MAPK activity
GO:0006987 TAS:ReactomePactivation of signaling protein activity involved in unfolded protein response
GO:0001525 IEA:UniProtKB-KWPangiogenesis
GO:0007596 TAS:ReactomePblood coagulation
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0030968 TAS:ReactomePendoplasmic reticulum unfolded protein response
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0007507 IEA:EnsemblPheart development
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 ISS:BHF-UCLPinsulin receptor signaling pathway
GO:0050900 TAS:ReactomePleukocyte migration
GO:0000165 IDA:UniProtKBPMAPK cascade
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0018108 TAS:GOCPpeptidyl-tyrosine phosphorylation
GO:0030168 TAS:ReactomePplatelet activation
GO:0008284 NAS:UniProtKBPpositive regulation of cell proliferation
GO:0045740 ISS:BHF-UCLPpositive regulation of DNA replication
GO:0007265 TAS:ReactomePRas protein signal transduction
GO:0007176 TAS:ProtIncPregulation of epidermal growth factor-activated receptor activity
GO:0040008 IEA:UniProtKB-KWPregulation of growth
GO:0016337 IEA:EnsemblPsingle organismal cell-cell adhesion
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_12051Cell surface interactions at the vascular wall
REACT_267817Constitutive Signaling by EGFRvIII
REACT_115852Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
REACT_75790Cytokine Signaling in Immune system
REACT_116125Disease
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_19184GPCR downstream signaling
REACT_19388G-protein beta:gamma signalling
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_1195Insulin receptor signalling cascade
REACT_15523Integrin alphaIIb beta3 signaling
REACT_27283Interleukin-2 signaling
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_23891Interleukin receptor SHC signaling
REACT_18368IRE1alpha activates chaperones
REACT_17015Metabolism of proteins
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_798Platelet activation, signaling and aggregation
REACT_278Platelet Aggregation (Plug Formation)
REACT_12579SHC1 events in EGFR signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_116005SHC1 events in ERBB4 signaling
REACT_1661SHC activation
REACT_661SHC-mediated signalling
REACT_999SHC-related events
REACT_150139SHC-related events triggered by IGF1R
REACT_508Signal attenuation
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_22232Signaling by Interleukins
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12033Signalling to RAS
REACT_111102Signal Transduction
REACT_12621Tie2 Signaling
REACT_18356Unfolded Protein Response (UPR)
REACT_18273XBP1(S) activates chaperone genes
SMP Pathway Links
SMP IDDescription
SMP00391Insulin Signalling
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