MGP Database

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MGP002843

Ontology/Pathway Information

Entrez Gene ID6502
Gene NameS-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Gene Symbol SKP2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016235 IDA:HPACaggresome
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005730 IDA:HPACnucleolus
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:HPACnucleus
GO:0019005 IDA:UniProtKBCSCF ubiquitin ligase complex
GO:0042802 IPI:IntActFidentical protein binding
GO:0004842 IEA:EnsemblFubiquitin-protein transferase activity
GO:0031145 TAS:ReactomePanaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0008283 TAS:ProtIncPcell proliferation
GO:0071460 IEA:EnsemblPcellular response to cell-matrix adhesion
GO:0000082 TAS:ReactomePG1/S transition of mitotic cell cycle
GO:0000086 IEA:EnsemblPG2/M transition of mitotic cell cycle
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0033148 IEA:EnsemblPpositive regulation of intracellular estrogen receptor signaling pathway
GO:0048661 IEA:EnsemblPpositive regulation of smooth muscle cell proliferation
GO:0000209 IEA:EnsemblPprotein polyubiquitination
GO:0051726 IEA:EnsemblPregulation of cell cycle
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_6761APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
REACT_6828APC/C-mediated degradation of cell cycle proteins
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_9029Cyclin A:Cdk2-associated events at S phase entry
REACT_821Cyclin D associated events in G1
REACT_1574Cyclin E associated events during G1/S transition
REACT_1590G1 Phase
REACT_1783G1/S Transition
REACT_6900Immune System
REACT_21267Mitotic G1-G1/S phases
REACT_21279Regulation of mitotic cell cycle
REACT_9003SCF(Skp2)-mediated degradation of p27/p21
REACT_899S Phase
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