MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002849

UniProt Annotations

Entry Information
Gene Namesolute carrier family 1 (neutral amino acid transporter), member 5
Protein EntryAAAT_HUMAN
UniProt IDQ15758
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing, Alternative initiation; Named isoforms=3; Comment=A number of isoforms are produced by alternative initiation. Isoforms start at multiple alternative CUG and GUG codons. {ECO:0000269|PubMed:11350958}; Name=1; IsoId=Q15758-1; Sequence=Displayed; Name=2; IsoId=Q15758-2; Sequence=VSP_046354; Note=No experimental confirmation available.; Name=3; IsoId=Q15758-3; Sequence=VSP_046851; Note=No experimental confirmation available.;
FunctionSodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349). {ECO:0000269|PubMed:10051606, ECO:0000269|PubMed:10196349, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:23492904}.
SimilarityBelongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A5 subfamily. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SubunitInteracts with ERVH48-1/suppressyn; may negatively regulate syncytialization. {ECO:0000269|PubMed:23492904}.
Tissue SpecificityPlacenta, lung, skeletal muscle, kidney, pancreas, and intestine.
  logo