MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002853

UniProt Annotations

Entry Information
Gene Namesolute carrier family 2 (facilitated glucose transporter), member 2
Protein EntryGTR2_HUMAN
UniProt IDP11168
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11168-1; Sequence=Displayed; Name=2; IsoId=P11168-2; Sequence=VSP_054835;
DiseaseFanconi-Bickel syndrome (FBS) [MIM:227810]: Rare, well- defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose. {ECO:0000269|PubMed:10987651, ECO:0000269|PubMed:11044475}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionFacilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.
PtmN-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells. {ECO:0000250}.
SimilarityBelongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
Tissue SpecificityLiver, insulin-producing beta cell, small intestine and kidney.
Web ResourceName=Wikipedia; Note=GLUT2 entry; URL="http://en.wikipedia.org/wiki/GLUT2";
  logo