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MGP002864

Record overview

MGPD IDMGP002864
Gene ID6528
SpeciesHomo sapiens (Human)
Gene Namesolute carrier family 5 (sodium/iodide cotransporter), member 5
Gene Symbol SLC5A5
SynonymsNIS; TDH1;
Alternate namessodium/iodide cotransporter; Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; solute carrier family 5 (sodium iodide symporter), member 5;
Chromosome19
Map Location19p13.11
SummaryThis gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009]
OrthologsView orthologs and multiple alignments for SLC5A5

Proteins

sodium/iodide cotransporter
Refseq ID:NP_000444
Protein GI:4507035
UniProt ID:Q92911
mRNA ID:NM_000453
Length:643
RefSeq Status:
MEAVETGERPTFGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAEDFFTGGRRLAALPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNSVL
TALLFMPVFYRLGLTSTYEYLEMRFSRAVRLCGTLQYIVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTFYTAVGGMKAVVWTDVFQVVVMLS
GFWVVLARGVMLVGGPRQVLTLAQNHSRINLMDFNPDPRSRYTFWTFVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKLALLINQVGLFLIVSSAACCG
IVMFVFYTDCDPLLLGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRLRSLAPRKLVIISKGLSLIYGSACLT
VAALSSLLGGGVLQGSFTVMGVISGPLLGAFILGMFLPACNTPGVLAGLGAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNASGLLDPALLP
ANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLTTVLCGALISCLTGPTKRSTLAPGLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKK
PPGFLPTNEDRLFFLGQKELEGAGSWTPCVGHDGGRDQQETNL
 
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