MGP Database

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MGP002867

Ontology/Pathway Information

Entrez Gene ID6531
Gene Namesolute carrier family 6 (neurotransmitter transporter), member 3
Gene Symbol SLC6A3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030424 IDA:UniProtKBCaxon
GO:0005737 TAS:ProtIncCcytoplasm
GO:0016021 TAS:ProtIncCintegral component of membrane
GO:0005887 IEA:InterProCintegral component of plasma membrane
GO:0043025 IDA:UniProtKBCneuronal cell body
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0035240 IEA:EnsemblFdopamine binding
GO:0005330 IEA:EnsemblFdopamine:sodium symporter activity
GO:0005329 IDA:UniProtKBFdopamine transmembrane transporter activity
GO:0008144 IEA:EnsemblFdrug binding
GO:0008504 IDA:MGIFmonoamine transmembrane transporter activity
GO:0021984 IEA:EnsemblPadenohypophysis development
GO:0007568 IEA:EnsemblPaging
GO:0098655 IDA:GOCPcation transmembrane transport
GO:0042416 IEA:EnsemblPdopamine biosynthetic process
GO:0042420 IEA:EnsemblPdopamine catabolic process
GO:0015872 IDA:UniProtKBPdopamine transport
GO:0007595 IEA:EnsemblPlactation
GO:0007626 IEA:EnsemblPlocomotory behavior
GO:0015844 IDA:MGIPmonoamine transport
GO:0042136 TAS:ReactomePneurotransmitter biosynthetic process
GO:0040018 IEA:EnsemblPpositive regulation of multicellular organism growth
GO:0060134 IEA:EnsemblPprepulse inhibition
GO:0042053 IEA:EnsemblPregulation of dopamine metabolic process
GO:0051591 IEA:EnsemblPresponse to cAMP
GO:0042220 IEA:EnsemblPresponse to cocaine
GO:0042493 IEA:EnsemblPresponse to drug
GO:0045471 IEA:EnsemblPresponse to ethanol
GO:0010039 IEA:EnsemblPresponse to iron ion
GO:0035094 IEA:EnsemblPresponse to nicotine
GO:0007608 IEA:EnsemblPsensory perception of smell
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0055085 TAS:ReactomePtransmembrane transport
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_15514Dopamine clearance from the synaptic cleft
REACT_20506Na+/Cl- dependent neurotransmitter transporters
REACT_13685Neuronal System
REACT_13583Neurotransmitter Clearance In The Synaptic Cleft
REACT_19118SLC-mediated transmembrane transport
REACT_15518Transmembrane transport of small molecules
REACT_13477Transmission across Chemical Synapses
REACT_19305Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
SMP Pathway Links
SMP IDDescription
SMP006793-Methylthiofentanyl Action Pathway
SMP00413Alfentanil Action Pathway
SMP00685Alvimopan Action Pathway
SMP00674Anileridine Action Pathway
SMP00392Benzocaine Action Pathway
SMP00393Bupivacaine Action Pathway
SMP00684Buprenorphine Action Pathway
SMP00414Carfentanil Action Pathway
SMP00394Chloroprocaine Action Pathway
SMP00424Citalopram Action Pathway
SMP00395Cocaine Action Pathway
SMP00405Codeine Action Pathway
SMP00423Desipramine Action Pathway
SMP00676Dezocine Action Pathway
SMP00396Dibucaine Action Pathway
SMP00689Dihydromorphine Action Pathway
SMP00680Dimethylthiambutene Action Pathway
SMP00675Diphenoxylate Action Pathway
SMP00425Escitalopram Action Pathway
SMP00681Ethylmorphine Action Pathway
SMP00415Fentanyl Action Pathway
SMP00426Fluoxetine Action Pathway
SMP00407Heroin Action Pathway
SMP00411Hydrocodone Action Pathway
SMP00410Hydromorphone Action Pathway
SMP00422Imipramine Action Pathway
SMP00690Ketobemidone Action Pathway
SMP00683Levallorphan Action Pathway
SMP00397Levobupivacaine Action Pathway
SMP00677Levomethadyl Acetate Action Action Pathway
SMP00673Levorphanol Action Pathway
SMP00398Lidocaine (Local Anaesthetic) Action Pathway
SMP00399Mepivacaine Action Pathway
SMP00408Methadone Action Pathway
SMP00678Methadyl Acetate Action Pathway
SMP00406Morphine Action Pathway
SMP00691Nalbuphine Action Pathway
SMP00688Naloxone Action Pathway
SMP00687Naltrexone Action Pathway
SMP00431Nicotine Action Pathway
SMP00400Oxybuprocaine Action Pathway
SMP00409Oxycodone Action Pathway
SMP00412Oxymorphone Action Pathway
SMP00686Pentazocine Action Pathway
SMP00401Prilocaine Action Pathway
SMP00402Procaine Action Pathway
SMP00403Proparacaine Action Pathway
SMP00672Propoxyphene Action Pathway
SMP00416Remifentanil Action Pathway
SMP00404Ropivacaine Action Pathway
SMP00417Sufentanil Action Pathway
SMP00671Tramadol Action Action Pathway
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