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MGP002875

UniProt Annotations

Entry Information
Gene Namesolute carrier family 6 (neurotransmitter transporter), member 13
Protein EntryS6A13_HUMAN
UniProt IDQ9NSD5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NSD5-1; Sequence=Displayed; Name=2; IsoId=Q9NSD5-2; Sequence=VSP_043070; Note=No experimental confirmation available.; Name=3; IsoId=Q9NSD5-3; Sequence=VSP_044887, VSP_044888;
Biophysicochemical PropertiesKinetic parameters: KM=3.7 uM for GABA {ECO:0000269|PubMed:17502375}; KM=20.2 uM for beta-alanine {ECO:0000269|PubMed:17502375};
FunctionSodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport. {ECO:0000269|PubMed:17502375, ECO:0000269|PubMed:22932902}.
Sequence CautionSequence=AAF64247.1; Type=Frameshift; Positions=542; Evidence={ECO:0000305};
SimilarityBelongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:22932902}; Multi-pass membrane protein {ECO:0000269|PubMed:22932902}.
Tissue SpecificityExpressed in brain, kidney, lung, liver and testis. {ECO:0000269|PubMed:11824941, ECO:0000269|PubMed:17502375}.
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