MGP Database

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MGP002877

UniProt Annotations

Entry Information
Gene Namesolute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Protein EntryCTR2_HUMAN
UniProt IDP52569
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CAT-2B; IsoId=P52569-1; Sequence=Displayed; Name=2; Synonyms=CAT-2A; IsoId=P52569-2; Sequence=VSP_037354, VSP_023354; Note=Ref.2 (AAB62810) sequence differs from that shown due to a frameshift in position 29. {ECO:0000305}; Name=3; IsoId=P52569-3; Sequence=VSP_037354; Note=No experimental confirmation available.;
FunctionFunctions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport. {ECO:0000250|UniProtKB:P18581, ECO:0000269|PubMed:9174363}.
Sequence CautionSequence=AAH69648.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI04906.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI13662.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI43584.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:9174363}; Multi-pass membrane protein {ECO:0000269|PubMed:9174363}.
Tissue SpecificityExpressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart. {ECO:0000269|PubMed:8954799}.
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