MGP Database

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MGP002880

UniProt Annotations

Entry Information
Gene Namesolute carrier family 8 (sodium/calcium exchanger), member 3
Protein EntryNAC3_HUMAN
UniProt IDP57103
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=7; Name=3; Synonyms=NCX3.3; IsoId=P57103-1; Sequence=Displayed; Name=2; Synonyms=NCX3.2; IsoId=P57103-2; Sequence=VSP_008116; Name=4; Synonyms=NCX3.4; IsoId=P57103-3; Sequence=VSP_008117, VSP_008118; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.; Name=5; Synonyms=NCX3-tN.1; IsoId=P57103-4; Sequence=VSP_043125; Note=Expressed in fetal brain.; Name=6; Synonyms=NCX3-tN.2; IsoId=P57103-5; Sequence=VSP_043126, VSP_008116; Note=Expressed in fetal brain.; Name=7; IsoId=P57103-6; Sequence=VSP_043850; Name=8; IsoId=P57103-7; Sequence=VSP_044502;
Enzyme RegulationBy intracellular calcium ions. {ECO:0000250}.
FunctionRapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity). {ECO:0000250}.
SimilarityBelongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. {ECO:0000305}.
SimilarityContains 2 Calx-beta domains. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
Tissue SpecificityIsoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle. {ECO:0000269|PubMed:15777725}.
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