MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002903

UniProt Annotations

Entry Information
Gene Namesolute carrier family 20 (phosphate transporter), member 1
Protein EntryS20A1_HUMAN
UniProt IDQ8WUM9
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=24.1 uM for phosphate {ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}; Vmax=1.9 nmol/min/mg enzyme (in the presence of 0.05-2 mM phosphate) {ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}; Note=With an increase in pH, a decrease in phosphate uptake is observed.; pH dependence: Optimum pH is 6.5 and 7.5. {ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748};
DomainRegion A confers human cells susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection.
FunctionSodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:1531369, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:7966619, ECO:0000269|PubMed:8041748}.
InductionBy phosphate deprivation as well as by IL8/interleukin- 8 in hypertrophic chondrocytes. {ECO:0000269|PubMed:15641067, ECO:0000269|PubMed:8041748}.
SimilarityBelongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
Tissue SpecificityUbiquitously expressed. {ECO:0000269|PubMed:2078500}.
  logo