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MGP002905

Record overview

MGPD IDMGP002905
Gene ID6576
SpeciesHomo sapiens (Human)
Gene Namesolute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
Gene Symbol SLC25A1
SynonymsCTP; SEA; D2L2AD; SLC20A3;
Alternate namestricarboxylate transport protein, mitochondrial; citrate transport protein; solute carrier family 20 (mitochondrial citrate transporter), member 3; tricarboxylate carrier protein;
Chromosome22
Map Location22q11.21
SummaryThis gene encodes a member of the mitochondrial carrier subfamily of solute carrier proteins. Members of this family include nuclear-encoded transporters that translocate small metabolites across the mitochondrial membrane. This protein regulates the movement of citrate across the inner membranes of the mitochondria. Mutations in this gene have been associated with combined D-2- and L-2-hydroxyglutaric aciduria. Pseudogenes of this gene have been identified on chromosomes 7, 11, 16, and 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
OrthologsView orthologs and multiple alignments for SLC25A1

Proteins

tricarboxylate transport protein, mitochondrial isoform a precursor
Refseq ID:NP_005975
Protein GI:21389315
UniProt ID:P53007
mRNA ID:NM_005984
Length:311
RefSeq Status:
MPAPRAPRALAAAAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAV
RFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFF
VMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEV
VKLLNKVWKTD
 
transit_peptide: 1..13
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (P53007.2)
calculated_mol_wt: 1293
peptide sequence: 
MPAPRAPRALAAA

mat_peptide: 14..311
product: Tricarboxylate transport protein, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P53007.2)
calculated_mol_wt: 32738
peptide sequence: 
APASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMR
DAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDN
PNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKVWKTD
 
tricarboxylate transport protein, mitochondrial isoform b
Refseq ID:NP_001243463
Protein GI:374717343
UniProt ID:D9HTE9
mRNA ID:NM_001256534
Length:318
RefSeq Status:
MFPAALARRPRRPKSGTGEGPERQRPGGSLRSGFPVPAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYG
SIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGS
NQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIV
FVIYDEVVKLLNKVWKTD
 
tricarboxylate transport protein, mitochondrial isoform c
Refseq ID:NP_001274316
Protein GI:568786339
UniProt ID:B4DP62
mRNA ID:NM_001287387
Length:208
RefSeq Status:
MFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMT
SLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKL
LNKVWKTD
 
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